Anti-ATG7 Antibody

ATG7 Antibody

ATG7 Antibody is a rabbit polyclonal antibody directed against ATG7, offered by Assay Genie for research applications. Reported applications include WB, ICC/IF and IHC. Reported reactivity: Human, Mouse and Rat. Purified by Peptide Affinity.

ATG7 is a pivotal E1-like enzyme essential for autophagosome biogenesis, a core process in cellular homeostasis and neuroprotection. Functioning in concert with ATG10, ATG7 catalyzes the conjugation of ATG12 to ATG5, a critical step in the formation of the autophagosome membrane. Additionally, ATG7 activates ATG8 (LC3/GABARAP family proteins), facilitating their lipidation and incorporation into autophagosomal membranes. This dual role positions ATG7 as a master regulator of autophagic flux. In the context of neuroscience, ATG7 has emerged as a key player in the maintenance of neuronal integrity. Its activity is vital for the clearance of misfolded proteins and damaged organelles—hallmarks of neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's disease. Conditional knockout models have demonstrated that loss of ATG7 in neurons leads to progressive neurodegeneration, underscoring its neuroprotective function. Moreover, ATG7 is critical for metabolic adaptation, particularly in neonates, where it ensures amino acid supply through autophagy during nutrient scarcity. This metabolic role further highlights its importance in brain development and function. Given its central role in autophagy and neuronal survival, ATG7 is a promising therapeutic target in neurodegenerative disease research. Ongoing studies aim to modulate ATG7 activity to restore autophagic balance and mitigate neurodegeneration. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.