Signal Transduction Antibodies 2
Anti-ASNA1 Antibody (CAB3746)
- SKU:
- CAB3746
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Antibody Name: | Anti-ASNA1 Antibody |
Antibody SKU: | CAB3746 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC IF |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-348 of human ASNA1 (NP_004308.2). |
Application: | WB IHC IF |
Recommended Dilution: | WB 1:200 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | U-251MG, MCF7, 293T, Mouse kidney, Mouse testis, Mouse brain, Mouse lung, Rat brain |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-348 of human ASNA1 (NP_004308.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | MAAG VAGW GVEA EEFE DAPD VEPL EPTL SNII EQRS LKWI FVGG KGGV GKTT CSCS LAVQ LSKG RESV LIIS TDPA HNIS DAFD QKFS KVPT KVKG YDNL FAME IDPS LGVA ELPD EFFE EDNM LSMG KKMM QEAM SAFP GIDE AMSY AEVM RLVK GMNF SVVV FDTA PTGH TLRL LNFP TIVE RGLG RLMQ IKNQ ISPF ISQM CNML GLGD MNAD QLAS KLEE TLPV IRSV SEQF KDPE QTTF ICVC IAEF LSLY ETER LIQE LAKC KIDT HNII VNQL VFPD PEKP CKMC EARH KIQA KYLD QMED LYED FHIV KLPL LPHE VRGA DKVN TFSA LLLE PYKP PSAQ |
Gene ID: | 439 |
Uniprot: | O43681 |
Cellular Location: | Cytoplasm, Endoplasmic reticulum, Nucleus, nucleolus |
Calculated MW: | 38kDa |
Observed MW: | 39kDa |
Synonyms: | ASNA1, ARSA-I, ARSA1, ASNA-I, GET3, TRC40, hASNA-I |
Background: | This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. |
UniProt Protein Function: | ASNA1: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling. Belongs to the arsA ATPase family. |
UniProt Protein Details: | Protein type:Nucleolus; EC 3.6.-.-; EC 3.6.3.16; Hydrolase Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: endoplasmic reticulum; cytoplasm; nucleolus; nucleus Molecular Function:arsenite transmembrane transporter activity; transporter activity; metal ion binding; ATPase activity; ATP binding Biological Process: protein insertion into ER membrane; transport; metabolic process; inorganic anion transport |
NCBI Summary: | This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011] |
UniProt Code: | O43681 |
NCBI GenInfo Identifier: | 6647417 |
NCBI Gene ID: | 439 |
NCBI Accession: | O43681.2 |
UniProt Secondary Accession: | O43681,Q53FC6, Q92849, A6NHP8, A8K740, |
UniProt Related Accession: | O43681 |
Molecular Weight: | Calculated: 38kDaObserved: 39kDa |
NCBI Full Name: | ATPase ASNA1 |
NCBI Synonym Full Names: | arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) |
NCBI Official Symbol: | ASNA1 |
NCBI Official Synonym Symbols: | GET3; ARSA1; TRC40; ARSA-I; ASNA-I; hASNA-I |
NCBI Protein Information: | ATPase ASNA1; golgi to ER traffic 3 homolog; transmembrane domain recognition complex, 40kDa; transmembrane domain recognition complex 40 kDa ATPase subunit |
UniProt Protein Name: | ATPase ASNA1 |
UniProt Synonym Protein Names: | Arsenical pump-driving ATPase; Arsenite-stimulated ATPase |
Protein Family: | ATPase |
UniProt Gene Name: | ASNA1 |
UniProt Entry Name: | ASNA_HUMAN |
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