Cell Biology Antibodies 13

Anti-ASIC4 Antibody (CAB17179)

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SKU:
CAB17179
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ASIC4 Antibody
Antibody SKU:CAB17179
Antibody Size:20uL, 50uL, 100uL
Application:IHC
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-460 of human ASIC4 (NP_878267.2).
Application:IHC
Recommended Dilution:IHC 1:50 - 1:200
Reactivity:Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-460 of human ASIC4 (NP_878267.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GLEI MLDI QQEE YLPI WRET NETS FEAG IRVQ IHSQ EEPP YIHQ LGFG VSPG FQTF VSCQ EQRL TYLP QPWG NCRA ESEL REPE LQGY SAYS VSAC RLRC EKEA VLQR CHC
Gene ID:55515
Uniprot:Q96FT7
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Anti-ASIC4 Antibody (CAB17179)Immunohistochemistry - ASIC4 Polyclonal Antibody (CAB17179)
Synonyms:ASIC4, ACCN4, BNAC4
Background:This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC.
UniProt Protein Function:ASIC4: Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC4 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Transporter, ion channel; Channel, sodium; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: integral to plasma membrane

Molecular Function:ion channel activity; sodium ion transmembrane transporter activity

Biological Process: transport

NCBI Summary:This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012]
UniProt Code:Q96FT7
NCBI GenInfo Identifier:296434387
NCBI Gene ID:55515
NCBI Accession:Q96FT7.2
UniProt Secondary Accession:Q96FT7,Q53SB7, Q6GMS1, Q6PIN9, Q9NQA4,
UniProt Related Accession:Q96FT7
Molecular Weight:72,190 Da
NCBI Full Name:Acid-sensing ion channel 4
NCBI Synonym Full Names:acid sensing ion channel subunit family member 4
NCBI Official Symbol:ASIC4  
NCBI Official Synonym Symbols:ACCN4; BNAC4  
NCBI Protein Information:acid-sensing ion channel 4
UniProt Protein Name:Acid-sensing ion channel 4
UniProt Synonym Protein Names:Amiloride-sensitive cation channel 4; Amiloride-sensitive cation channel 4, pituitary
Protein Family:Acid-sensing ion channel
UniProt Gene Name:ASIC4  
UniProt Entry Name:ASIC4_HUMAN
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