Epigenetics & Nuclear Signaling Antibodies 5

Anti-ASH2L Antibody (CAB4892)

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SKU:
CAB4892
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ASH2
Synonyms:
ASH2L1
Synonyms:
ASH2L2
Synonyms:
Bre2
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:ASH2L Rabbit mAb
Product Code:CAB4892
Size:20uL, 50uL, 100uL
Synonyms:ASH2, ASH2L1, ASH2L2, Bre2
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ASH2L
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:PC-3, Mouse lung, Mouse testis
Immunogen:A synthesized peptide derived from human ASH2L
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9070
Uniprot:Q9UBL3
Calculated MW:69kDa
Observed MW:65KDa/80KDa
UniProt Protein Function:ASH2L: Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis. Interacts with HCFC1. Core component of several methyltransferase-containing complexes including MLL1/MLL, ASCOM, MLL2/MLL3 and MLL3/MLL4. Each complex is at least composed of ASH2L, RBBP5, DPY30, WDR5, one or more specific histone methyltransferases (MLL, MLL2, MLL3 and MLL4), and the facultative components C16orf53/PA1, C17orf49, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with DPY30 and RBBP5; the interaction is direct. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Interacts with SETD1A and SETD1B. Ubiquitously expressed. Predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription regulation; Methyltransferase

Chromosomal Location of Human Ortholog: 8p11.2

Cellular Component: histone methyltransferase complex; nucleoplasm; nucleus

Molecular Function:beta-catenin binding; DNA binding; histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; protein binding

Biological Process: histone H3-K4 methylation; positive regulation of cell proliferation; response to DNA damage stimulus; response to estrogen stimulus; transcription from RNA polymerase II promoter

UniProt Code:Q9UBL3
NCBI GenInfo Identifier:32141382
NCBI Gene ID:9070
NCBI Accession:Q9UBL3.1
UniProt Secondary Accession:Q9UBL3,O60659, O60660, Q96B62, A8K7C3, D3DSW9,
UniProt Related Accession:Q9UBL3
Molecular Weight:60,208 Da
NCBI Full Name:Set1/Ash2 histone methyltransferase complex subunit ASH2
NCBI Synonym Full Names:ASH2 like histone lysine methyltransferase complex subunit
NCBI Official Symbol:ASH2L  
NCBI Official Synonym Symbols:ASH2; Bre2; ASH2L1; ASH2L2  
NCBI Protein Information:set1/Ash2 histone methyltransferase complex subunit ASH2
UniProt Protein Name:Set1/Ash2 histone methyltransferase complex subunit ASH2
UniProt Synonym Protein Names:ASH2-like protein
UniProt Gene Name:ASH2L  
UniProt Entry Name:ASH2L_HUMAN
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