Signal Transduction Antibodies 2

Anti-ASB7 Antibody (CAB16596)

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SKU:
CAB16596
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-ASB7 Antibody
Antibody SKU:CAB16596
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human ASB7 (NP_078984.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human ASB7 (NP_078984.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MLHH HCRR NPEL QEEL QIQA AVAA GDVH TVRK MLEQ GYSP NGRD ANGW TLLH FSAA RGKE RCVR VFLE HGAD PTVK DLIG GFTA LHYA AMHG RARI ARLM LESE YRSD IINA KSND GWTP LHVA AHYG RDSF VRLL LEFK AEVD PLSD KGTT PLQL AIIR ERSS CVKI LLDH NANI DIQN GFLL RYAV IKSN HSYC RMFL QRGA DTNL GRLE DGQT PLHL SALR DDVL CARM LYNY GADT NTRN YEGQ TPLA VSIS ISGS SRPC LDFL QEVT SM
Gene ID:140460
Uniprot:Q9H672
Cellular Location:
Calculated MW:30kDa/36kDa
Observed MW:36kDa
Synonyms:ASB7
Background:The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described.
UniProt Protein Function:ASB7: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 15q26.3

Molecular Function:protein binding

NCBI Summary:The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Code:Q9H672
NCBI GenInfo Identifier:38372887
NCBI Gene ID:140460
NCBI Accession:Q9H672.2
UniProt Secondary Accession:Q9H672,Q6GSJ6, Q7Z4S3, A8K1E5,
UniProt Related Accession:Q9H672
Molecular Weight:30,713 Da
NCBI Full Name:Ankyrin repeat and SOCS box protein 7
NCBI Synonym Full Names:ankyrin repeat and SOCS box containing 7
NCBI Official Symbol:ASB7  
NCBI Protein Information:ankyrin repeat and SOCS box protein 7
UniProt Protein Name:Ankyrin repeat and SOCS box protein 7
Protein Family:Ankyrin repeat and SOCS box protein
UniProt Gene Name:ASB7  
UniProt Entry Name:ASB7_HUMAN
Anti-ASB7 Antibody (CAB16596)Western blot analysis of extracts of mouse brain, using ASB7 antibody (CAB16596) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.
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