Signal Transduction Antibodies 1

Anti-ASB5 Antibody (CAB14449)

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SKU:
CAB14449
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-ASB5 Antibody
Antibody SKU:CAB14449
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 130-329 of human ASB5 (NP_543150.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293T, A-431, HeLa, HepG2, Raji
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 130-329 of human ASB5 (NP_543150.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NAIT IDGV TPLF NACS QGSP SCAE LLLE YGAK AQLE SCLP SPTH EAAS KGHH ECLD ILIS WGID VDQE IPHL GTPL YVAC MSQQ FHCI WKLL YAGA DVQK GKYW DTPL HAAA QQSS TEIV NLLL EFGA DINA KNTE LLRP IDVA TSSS MVER ILLQ HEAT PSSL YQLC RLCI RSYI GKPR LHLI PQLQ LPTL LKNF LQYR
Gene ID:140458
Uniprot:Q8WWX0
Cellular Location:
Calculated MW:30kDa/36kDa
Observed MW:36kDa
Synonyms:ASB5, ASB-5
Background:The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.
UniProt Protein Function:ASB5: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May play a role in the initiation of arteriogenesis.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 4q34.2

Biological Process: protein ubiquitination

NCBI Summary:The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known. [provided by RefSeq, Jul 2008]
UniProt Code:Q8WWX0
NCBI GenInfo Identifier:18254476
NCBI Gene ID:140458
NCBI Accession:NP_543150.1
UniProt Secondary Accession:Q8WWX0,Q8N7B5,
UniProt Related Accession:Q8WWX0
Molecular Weight:30,083 Da
NCBI Full Name:ankyrin repeat and SOCS box protein 5
NCBI Synonym Full Names:ankyrin repeat and SOCS box containing 5
NCBI Official Symbol:ASB5  
NCBI Official Synonym Symbols:ASB-5  
NCBI Protein Information:ankyrin repeat and SOCS box protein 5; SOCS box protein ASB-5; ankyrin repeat and SOCS box-containing 5
UniProt Protein Name:Ankyrin repeat and SOCS box protein 5
Protein Family:Ankyrin repeat and SOCS box protein
UniProt Gene Name:ASB5  
UniProt Entry Name:ASB5_HUMAN
Anti-ASB5 Antibody (CAB14449)Western blot analysis of extracts of various cell lines, using ASB5 antibody (CAB14449) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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