Cell Biology Antibodies 13

Anti-ASB4 Antibody (CAB17159)

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SKU:
CAB17159
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ASB4 Antibody
Antibody SKU:CAB17159
Antibody Size:20uL, 50uL, 100uL
Application:IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ASB4 (NP_665879.1).
Application:IHC
Recommended Dilution:IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ASB4 (NP_665879.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDGT TAPV TKSG AAKL VKRN FLEA LKSN DFGK LKAI LIQR QIDV DTVF EVED ENMV LASY KQGY WLPS YKLK SSWA TGLH LSVL FGHV ECLL VLLD HNAT INCR PNGK TPLH VACE MANV DCVK ILCD RGAK LNCY SLSG HTAL HFCT TPSS ILCA KQLV WRGA NVNM KTNN QDEE TPLH TAAH FGLS ELVA FYVE HGAI VDSV NAHM ETPL AIAA YWAL RFKE QEYS TEHH LVCR MLLD YKAE VNAR DDDF KSPL HKAA WNCD HVLM HMML EAGA EANL MDIN GCAA IQYV LKVT SVRP
Gene ID:51666
Uniprot:Q9Y574
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Anti-ASB4 Antibody (CAB17159)Immunohistochemistry - ASB4 Polyclonal Antibody (CAB17159)
Synonyms:ASB4, ASB-4
Background:The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known.
UniProt Protein Function:ASB4: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 7q21-q22

Cellular Component: Cul2-RING ubiquitin ligase complex; Cul5-RING ubiquitin ligase complex

NCBI Summary:The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y574
NCBI GenInfo Identifier:20532003
NCBI Gene ID:51666
NCBI Accession:Q9Y574.1
UniProt Secondary Accession:Q9Y574,O14586, Q14D68, Q8TBT2, A4D1H6,
UniProt Related Accession:Q9Y574
Molecular Weight:38,931 Da
NCBI Full Name:Ankyrin repeat and SOCS box protein 4
NCBI Synonym Full Names:ankyrin repeat and SOCS box containing 4
NCBI Official Symbol:ASB4  
NCBI Official Synonym Symbols:ASB-4  
NCBI Protein Information:ankyrin repeat and SOCS box protein 4
UniProt Protein Name:Ankyrin repeat and SOCS box protein 4
Protein Family:Ankyrin repeat and SOCS box protein
UniProt Gene Name:ASB4  
UniProt Entry Name:ASB4_HUMAN
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