Cell Biology Antibodies 15

Anti-ASB2 Antibody (CAB17923)

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SKU:
CAB17923
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ASB2 Antibody
Antibody SKU:CAB17923
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 448-587 of human ASB2 (NP_057234.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:293T, rat spleen, rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 448-587 of human ASB2 (NP_057234.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDLG CDGE PCFS CLYG NGPH PPAP QPSS RFND APAA DKEP SVVQ FCEF VSAP EVSR WAGP IIDV LLDY VGNV QLCS RLKE HIDS FEDW AVIK EKAE PPRP LAHL CRLR VRKA IGKY RIKL LDTL PLPG RLIR YLKY ENTQ
Gene ID:51676
Uniprot:Q96Q27
Cellular Location:
Calculated MW:65kDa
Observed MW:65kDa
Anti-ASB2 Antibody (CAB17923)Western blot - ASB2 Polyclonal Antibody (CAB17923)
Synonyms:ASB-2, ASB2
Background:This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniProt Protein Function:ASB2: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 14q31-q32

Molecular Function:protein binding

Biological Process: positive regulation of defense response to virus by host; signal transduction

NCBI Summary:This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
UniProt Code:Q96Q27
NCBI GenInfo Identifier:20531999
NCBI Gene ID:51676
NCBI Accession:Q96Q27.1
UniProt Secondary Accession:Q96Q27,Q9NSU5, Q9Y567, B2RDP9, B4E166,
UniProt Related Accession:Q96Q27
Molecular Weight:70,212 Da
NCBI Full Name:Ankyrin repeat and SOCS box protein 2
NCBI Synonym Full Names:ankyrin repeat and SOCS box containing 2
NCBI Official Symbol:ASB2  
NCBI Official Synonym Symbols:ASB-2  
NCBI Protein Information:ankyrin repeat and SOCS box protein 2
UniProt Protein Name:Ankyrin repeat and SOCS box protein 2
Protein Family:Anthranilate synthase
UniProt Gene Name:ASB2  
UniProt Entry Name:ASB2_HUMAN
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