Signal Transduction Antibodies 2
Anti-ASB13 Antibody (CAB15897)
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- SKU:
- CAB15897
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-ASB13 Antibody |
| Antibody SKU: | CAB15897 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 179-278 of human ASB13 (NP_078977.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 179-278 of human ASB13 (NP_078977.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AKLH ETAL HHAA KVKN VDLI EMLI EFGG NIYA RDNR GKKP SDYT WSSS APAK CFEY YEKT PLTL SQLC RVNL RKAT GVRG LEKI AKLN IPPR LIDY LSYN |
| Gene ID: | 79754 |
| Uniprot: | Q8WXK3 |
| Cellular Location: | |
| Calculated MW: | 18kDa/30kDa |
| Observed MW: | 30kDa |
| Synonyms: | ASB13 |
| Background: | The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants, both protein-coding and not protein-coding, have been described for this gene. |
| UniProt Protein Function: | ASB13: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 10p15.1 Molecular Function:protein binding Biological Process: protein ubiquitination |
| NCBI Summary: | The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants, both protein-coding and not protein-coding, have been described for this gene. [provided by RefSeq, Nov 2010] |
| UniProt Code: | Q8WXK3 |
| NCBI GenInfo Identifier: | 22208957 |
| NCBI Gene ID: | 79754 |
| NCBI Accession: | NP_078977.2 |
| UniProt Secondary Accession: | Q8WXK3,Q96EP7, Q9H8Z1, A8K7Q6, D3DRR2, |
| UniProt Related Accession: | Q8WXK3 |
| Molecular Weight: | 18,205 Da |
| NCBI Full Name: | ankyrin repeat and SOCS box protein 13 |
| NCBI Synonym Full Names: | ankyrin repeat and SOCS box containing 13 |
| NCBI Official Symbol: | ASB13 |
| NCBI Protein Information: | ankyrin repeat and SOCS box protein 13; ankyrin repeat and SOCS box-containing 13; ankyrin repeat domain-containing SOCS box protein Asb-13 |
| UniProt Protein Name: | Ankyrin repeat and SOCS box protein 13 |
| Protein Family: | Ankyrin repeat and SOCS box protein |
| UniProt Gene Name: | ASB13 |
| UniProt Entry Name: | ASB13_HUMAN |
 | Western blot analysis of extracts of mouse kidney, using ASB13 antibody (CAB15897) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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