Cell Biology Antibodies 11
Anti-ARTN Antibody (CAB7949)
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- SKU:
- CAB7949
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ARTN Antibody |
| Antibody SKU: | CAB7949 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human ARTN |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 22Rv1 |
| Immunogen: | A synthetic peptide of human ARTN |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9048 |
| Uniprot: | Q5T4W7 |
| Cellular Location: | Secreted |
| Calculated MW: | 22kDa/23kDa/24kDa |
| Observed MW: | 28kDa |
| Synonyms: | ARTN, ART, ENOVIN, EVN, NBN, artemin |
| Background: | This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma. |
| UniProt Protein Function: | artemin: Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Belongs to the TGF-beta family. GDNF subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: extracellular space Molecular Function:growth factor activity; receptor binding Biological Process: axon guidance; neuroblast proliferation; signal transduction; peripheral nervous system development; induction of positive chemotaxis |
| NCBI Summary: | The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q5T4W7 |
| NCBI GenInfo Identifier: | 74744994 |
| NCBI Gene ID: | 9048 |
| NCBI Accession: | Q5T4W7.1 |
| UniProt Secondary Accession: | Q5T4W7,O95441, O96030, Q6P6A3, D3DPY1, D3DPY3, |
| UniProt Related Accession: | Q5T4W7 |
| Molecular Weight: | 23,616 Da |
| NCBI Full Name: | Artemin |
| NCBI Synonym Full Names: | artemin |
| NCBI Official Symbol: | ARTN |
| NCBI Official Synonym Symbols: | EVN; NBN; ENOVIN |
| NCBI Protein Information: | artemin; neublastin; neurotrophic factor |
| UniProt Protein Name: | Artemin |
| UniProt Synonym Protein Names: | Enovin; Neublastin |
| Protein Family: | Artemin |
| UniProt Gene Name: | ARTN |
| UniProt Entry Name: | ARTN_HUMAN |
 | Western blot analysis of extracts of 22Rv1 cells, using ARTN antibody (CAB7949) at 1:500 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s. |
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