Signal Transduction Antibodies 1

Anti-ARR3 Antibody (CAB13009)

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SKU:
CAB13009
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-ARR3 Antibody
Antibody SKU:CAB13009
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ARR3 (NP_004303.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse eye, Rat eye
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ARR3 (NP_004303.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSKV FKKT SSNG KLSI YLGK RDFV DHVD TVEP IDGV VLVD PEYL KCRK LFVM LTCA FRYG RDDL EVIG LTFR KDLY VQTL QVVP AESS SPQG PLTV LQER LLHK LGDN AYPF TLQM VTNL PCSV TLQP GPED AGKP CGID FEVK SFCA ENPE ETVS KRDY VRLV VRKV QFAP PEAG PGPS AQTI RRFL LSAQ PLQL QAWM DREV HYHG EPIS VNVS INNC TNKV IKKI KISV DQIT DVVL YSLD KYTK TVFI QEFT ETVA
Gene ID:407
Uniprot:P36575
Cellular Location:
Calculated MW:39kDa/42kDa
Observed MW:42kDa
Synonyms:ARR3, ARRX, cArr
Background:The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function.
UniProt Protein Function:ARR3: May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins. Belongs to the arrestin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: Xcen-q21

Cellular Component: cytoplasm; photoreceptor inner segment; photoreceptor outer segment; synapse

Molecular Function:opsin binding; phosphoprotein binding; protein binding; protein domain specific binding

Biological Process: endocytosis; regulation of protein amino acid phosphorylation; signal transduction; visual perception

UniProt Code:P36575
NCBI GenInfo Identifier:93189450
NCBI Gene ID:407
NCBI Accession:P36575.2
UniProt Secondary Accession:P36575,Q5JT23, Q5JT24, Q6IBF5, Q96EN2, B5B0B9,
UniProt Related Accession:P36575
Molecular Weight:
NCBI Full Name:Arrestin-C
NCBI Synonym Full Names:arrestin 3 retinal (X-arrestin)
NCBI Official Symbol:ARR3  
NCBI Official Synonym Symbols:ARRX  
NCBI Protein Information:arrestin-C
UniProt Protein Name:Arrestin-C
UniProt Synonym Protein Names:Cone arrestin; C-arrestin; cArr; Retinal cone arrestin-3; X-arrestin
Protein Family:Arrestin
UniProt Gene Name:ARR3  
UniProt Entry Name:ARRC_HUMAN
Anti-ARR3 Antibody (CAB13009)Western blot analysis of extracts of various cell lines, using ARR3 antibody (CAB13009) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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