Anti-ARPC2 Antibody (CAB1382)

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SKU:
CAB1382
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ARPC2
Synonyms:
ARC34
Synonyms:
PNAS-139
Synonyms:
PRO2446
Synonyms:
p34-Arc
Synonyms:
actin-related protein 2/3 complex subunit 2
Research Area:
Cell Biology

Description

Product Name:ARPC2 Rabbit mAb
Product Code:CAB1382
Size:20uL, 50uL, 100uL
Synonyms:ARPC2, ARC34, PNAS-139, PRO2446, p34-Arc, actin-related protein 2/3 complex subunit 2
Applications:WB, IF, IP
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ARPC2.
Applications:WB, IF, IP
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200 IP 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, Mouse spleen, Mouse stomach, Mouse thymus, Rat lung
Immunogen:A synthesized peptide derived from human ARPC2.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10109
Uniprot:O15144
Cellular Location:Cell junction, Cell projection, Cytoplasm, cytoskeleton, synapse, synaptosome
Calculated MW:34kDa
Observed MW:34KDa
UniProt Protein Function:ARPC2: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament. Belongs to the ARPC2 family.
UniProt Protein Details:

Protein type:Actin-binding; Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 2q36.1

Cellular Component: Golgi apparatus; Arp2/3 protein complex; neuron projection; focal adhesion; cytoplasm; leading edge; plasma membrane; synapse; cytosol; endosome; actin cytoskeleton

Molecular Function:actin filament binding; protein binding; structural constituent of cytoskeleton; kinesin binding

Biological Process: axon guidance; ephrin receptor signaling pathway; innate immune response; cell motility

NCBI Summary:This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:O15144
NCBI GenInfo Identifier:3121764
NCBI Gene ID:10109
NCBI Accession:O15144.1
UniProt Secondary Accession:O15144,Q92801, Q9P1D4,
UniProt Related Accession:O15144
Molecular Weight:34,333 Da
NCBI Full Name:Actin-related protein 2/3 complex subunit 2
NCBI Synonym Full Names:actin related protein 2/3 complex, subunit 2, 34kDa
NCBI Official Symbol:ARPC2  
NCBI Official Synonym Symbols:ARC34; PRO2446; p34-Arc; PNAS-139  
NCBI Protein Information:actin-related protein 2/3 complex subunit 2; ARP2/3 protein complex subunit 34; arp2/3 complex 34 kDa subunit
UniProt Protein Name:Actin-related protein 2/3 complex subunit 2
UniProt Synonym Protein Names:Arp2/3 complex 34 kDa subunit; p34-ARC
UniProt Gene Name:ARPC2  
UniProt Entry Name:ARPC2_HUMAN
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