Cell Biology Antibodies 17

Anti-Arp2 Antibody (CAB8876)

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SKU:
CAB8876
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-Arp2 Antibody
Antibody SKU:CAB8876
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Arp2
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, HepG2, MCF7, NIH/3T3, C6, Mouse brain, Mouse thymus, Rat spleen, Rat kidney
Immunogen:A synthesized peptide derived from human Arp2
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10097
Uniprot:P61160
Cellular Location:
Calculated MW:37kDa
Observed MW:45KDa
Synonyms:ARP2
Background:The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Protein Function:ARP2: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Belongs to the actin family. ARP2 subfamily.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Actin-binding; Cytoskeletal

Chromosomal Location of Human Ortholog: 2p14

Cellular Component: Arp2/3 protein complex; focal adhesion; cell projection; membrane; cytoplasm; cytosol; actin cap; actin cytoskeleton

Molecular Function:actin filament binding; structural constituent of cytoskeleton; ATP binding

Biological Process: axon guidance; meiotic chromosome movement towards spindle pole; asymmetric cell division; ephrin receptor signaling pathway; establishment and/or maintenance of cell polarity; innate immune response; cilium biogenesis; cytokinesis after meiosis; cell motility; cytoplasmic transport; spindle localization

NCBI Summary:The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P61160
NCBI GenInfo Identifier:47117648
NCBI Gene ID:10097
NCBI Accession:P61160.1
UniProt Secondary Accession:P61160,O15142, Q96C82, B2RCP5, D6W5F4, E9PF41,
UniProt Related Accession:P61160
Molecular Weight:394
NCBI Full Name:Actin-related protein 2
NCBI Synonym Full Names:ARP2 actin-related protein 2 homolog (yeast)
NCBI Official Symbol:ACTR2  
NCBI Official Synonym Symbols:ARP2  
NCBI Protein Information:actin-related protein 2; actin-like protein 2
UniProt Protein Name:Actin-related protein 2
UniProt Synonym Protein Names:Actin-like protein 2
UniProt Gene Name:ACTR2  
UniProt Entry Name:ARP2_HUMAN
Anti-Arp2 Antibody (CAB8876)Western blot - Arp2 Rabbit mAb (CAB8876)
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