Antibody Name:	ARNT2 Rabbit Polyclonal Antibody
Antibody SKU:	CAB8060
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 440-690 of human ARNT2 (NP_055677.3).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	Mouse brain, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 440-690 of human ARNT2 (NP_055677.3).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	QLQQ QQAE LEVH QRDG LSSY DLSQ VPVP NLPA GVHE AGKS VEKA DAIF SQER DPRF AEMF AGIS ASEK KMMS SASA AGTQ QIYS QGSP FPSG HSGK AFSS SVVH VPGV NDIQ SSSS TGQN MSQI SRQL NQSQ VAWT GSRP PFPG QQIP SQSS KTQS SPFG IGTS HTYP ADPS SYSP LSSP ATSS PSGN AYSS LANR TPGF AESG QSSG QFQG RPSE VWSQ WQSQ HHGQ QSGE QHSH QQPG QTEV FQDM LPM
Gene ID:	9915
Uniprot:	Q9HBZ2
Cellular Location:	Nucleus
Calculated MW:	77kDa/78kDa
Observed MW:	79-85kDa

Synonyms:

ARNT2, WEDAS, bHLHe1

Background:

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.

UniProt Protein Function:	Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed:24022475). Specifically recognizes the xenobiotic response element (XRE).
NCBI Summary:	This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Dec 2013]
UniProt Code:	Q9HBZ2
NCBI GenInfo Identifier:	125987793
NCBI Gene ID:	9915
NCBI Accession:	Q9HBZ2.2
UniProt Secondary Accession:	Q9HBZ2,O15024, Q8IYC2, B4DIS7,
UniProt Related Accession:	Q9HBZ2
Molecular Weight:	77,612 Da
NCBI Full Name:	Aryl hydrocarbon receptor nuclear translocator 2
NCBI Synonym Full Names:	aryl hydrocarbon receptor nuclear translocator 2
NCBI Official Symbol:	ARNT2
NCBI Official Synonym Symbols:	WEDAS; bHLHe1
NCBI Protein Information:	aryl hydrocarbon receptor nuclear translocator 2
UniProt Protein Name:	Aryl hydrocarbon receptor nuclear translocator 2
UniProt Synonym Protein Names:	Class E basic helix-loop-helix protein 1; bHLHe1
Protein Family:	Aryl hydrocarbon receptor nuclear translocator
UniProt Gene Name:	ARNT2

	Western blot analysis of extracts of various cell lines, using ARNT2 antibody (CAB8060) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded human kidney using ARNT2 antibody (CAB8060) at dilution of 1:100 (40x lens).