Name: Anti-ARL6IP5 Antibody (CAB14842)
Brand: Signal Transduction Antibodies 1
SKU: CAB14842
Availability: OutOfStock

Antibody Name:	Anti-ARL6IP5 Antibody
Antibody SKU:	CAB14842
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse
Host Species:	Rabbit
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human ARL6IP5 (NP_006398.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse
Positive Samples:	Mouse thymus

Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human ARL6IP5 (NP_006398.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	TFVM VVML ASYF LISM FGGV MVFV FGIT FPLL LMFI HASL RLRN LKNK LENK MEGI GLKR TPMG IVLD ALEQ QEEG INRL TDYI SKVK E
Gene ID:	10550
Uniprot:	O75915
Cellular Location:	Cytoplasm, Endoplasmic reticulum membrane, Multi-pass membrane protein
Calculated MW:	21kDa
Observed MW:	22kDa

Synonyms:

ARL6IP5, DERP11, GTRAP3-18, HSPC127, JWA, PRAF3, Yip6b, addicsin, hp22, jmx

Background:

Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport.

UniProt Protein Function:	ARL6IP5: Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic. Belongs to the PRA1 family.
UniProt Protein Details:	Protein type:Membrane protein, integral; Membrane protein, multi-pass; Cytoskeletal; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 3p14 Cellular Component: endoplasmic reticulum; membrane Molecular Function:protein binding Biological Process: induction of apoptosis by oxidative stress; L-glutamate transport; negative regulation of L-glutamate transport; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of stress-activated MAPK cascade
NCBI Summary:	Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008]
UniProt Code:	O75915
NCBI GenInfo Identifier:	57012996
NCBI Gene ID:	10550
NCBI Accession:	O75915.1
UniProt Secondary Accession:	O75915,Q53ES3, Q5KU08, B2R6V5,
UniProt Related Accession:	O75915
Molecular Weight:	21,615 Da
NCBI Full Name:	PRA1 family protein 3
NCBI Synonym Full Names:	ADP ribosylation factor like GTPase 6 interacting protein 5
NCBI Official Symbol:	ARL6IP5
NCBI Official Synonym Symbols:	JWA; jmx; hp22; PRAF3; Yip6b; DERP11; HSPC127; addicsin; GTRAP3-18
NCBI Protein Information:	PRA1 family protein 3
UniProt Protein Name:	PRA1 family protein 3
UniProt Synonym Protein Names:	ADP-ribosylation factor-like protein 6-interacting protein 5; ARL-6-interacting protein 5; Aip-5; Cytoskeleton-related vitamin A-responsive protein; Dermal papilla-derived protein 11; GTRAP3-18; Glutamate transporter EAAC1-interacting protein; JM5; Prenylated Rab acceptor protein 2; Protein JWa; Putative MAPK-activating protein PM27
Protein Family:	PRA1 family protein
UniProt Gene Name:	ARL6IP5
UniProt Entry Name:	PRAF3_HUMAN

Western blot analysis of extracts of mouse thymus, using ARL6IP5 antibody (CAB14842) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.

Antibodies

ARL6IP5 Antibody (PACO07850)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)