Signal Transduction Antibodies 1
Anti-ARL6IP5 Antibody (CAB14842)
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- SKU:
- CAB14842
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-ARL6IP5 Antibody |
| Antibody SKU: | CAB14842 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human ARL6IP5 (NP_006398.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse thymus |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human ARL6IP5 (NP_006398.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TFVM VVML ASYF LISM FGGV MVFV FGIT FPLL LMFI HASL RLRN LKNK LENK MEGI GLKR TPMG IVLD ALEQ QEEG INRL TDYI SKVK E |
| Gene ID: | 10550 |
| Uniprot: | O75915 |
| Cellular Location: | Cytoplasm, Endoplasmic reticulum membrane, Multi-pass membrane protein |
| Calculated MW: | 21kDa |
| Observed MW: | 22kDa |
| Synonyms: | ARL6IP5, DERP11, GTRAP3-18, HSPC127, JWA, PRAF3, Yip6b, addicsin, hp22, jmx |
| Background: | Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. |
| UniProt Protein Function: | ARL6IP5: Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic. Belongs to the PRA1 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Cytoskeletal; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 3p14 Cellular Component: endoplasmic reticulum; membrane Molecular Function:protein binding Biological Process: induction of apoptosis by oxidative stress; L-glutamate transport; negative regulation of L-glutamate transport; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of stress-activated MAPK cascade |
| NCBI Summary: | Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75915 |
| NCBI GenInfo Identifier: | 57012996 |
| NCBI Gene ID: | 10550 |
| NCBI Accession: | O75915.1 |
| UniProt Secondary Accession: | O75915,Q53ES3, Q5KU08, B2R6V5, |
| UniProt Related Accession: | O75915 |
| Molecular Weight: | 21,615 Da |
| NCBI Full Name: | PRA1 family protein 3 |
| NCBI Synonym Full Names: | ADP ribosylation factor like GTPase 6 interacting protein 5 |
| NCBI Official Symbol: | ARL6IP5 |
| NCBI Official Synonym Symbols: | JWA; jmx; hp22; PRAF3; Yip6b; DERP11; HSPC127; addicsin; GTRAP3-18 |
| NCBI Protein Information: | PRA1 family protein 3 |
| UniProt Protein Name: | PRA1 family protein 3 |
| UniProt Synonym Protein Names: | ADP-ribosylation factor-like protein 6-interacting protein 5; ARL-6-interacting protein 5; Aip-5; Cytoskeleton-related vitamin A-responsive protein; Dermal papilla-derived protein 11; GTRAP3-18; Glutamate transporter EAAC1-interacting protein; JM5; Prenylated Rab acceptor protein 2; Protein JWa; Putative MAPK-activating protein PM27 |
| Protein Family: | PRA1 family protein |
| UniProt Gene Name: | ARL6IP5 |
| UniProt Entry Name: | PRAF3_HUMAN |
 | Western blot analysis of extracts of mouse thymus, using ARL6IP5 antibody (CAB14842) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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