Signal Transduction Antibodies 3

Anti-AQP4 Antibody (CAB11210)

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SKU:
CAB11210
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-AQP4 Antibody
Antibody SKU:CAB11210
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human AQP4
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Mouse, Rat
Positive Samples:Rat brain
Immunogen:A synthesized peptide derived from human AQP4
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:361
Uniprot:P55087
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:kDa
Observed MW:30KDa
Anti-AQP4 AntibodyWestern blot - AQP4 Rabbit mAb (CAB11210)
Synonyms:MIWC, WCH4
Background:This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]
UniProt Protein Function:AQP4: a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The predominant aquaporin found in brain. Two alternatively spliced transcript variants have been described
UniProt Protein Details:

Protein type:Transporter, aquaporin family; Membrane protein, integral; Channel, misc.; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 18q11.2-q12.1

Cellular Component: basolateral plasma membrane; cytoplasm; external side of plasma membrane; integral to membrane; plasma membrane

Molecular Function:glycerol channel activity; water channel activity; water transporter activity

Biological Process: glycerol transport; multicellular organismal water homeostasis; renal water homeostasis; transmembrane transport; transport; water transport

NCBI Summary:This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]
UniProt Code:P55087
NCBI GenInfo Identifier:2506859
NCBI Gene ID:361
NCBI Accession:P55087.2
UniProt Secondary Accession:P55087,P78564,
UniProt Related Accession:P55087
Molecular Weight:32,300 Da
NCBI Full Name:Aquaporin-4
NCBI Synonym Full Names:aquaporin 4
NCBI Official Symbol:AQP4  
NCBI Official Synonym Symbols:MIWC; WCH4  
NCBI Protein Information:aquaporin-4
UniProt Protein Name:Aquaporin-4
UniProt Synonym Protein Names:Mercurial-insensitive water channel; MIWC; WCH4
Protein Family:Aquaporin
UniProt Gene Name:AQP4  
UniProt Entry Name:AQP4_HUMAN
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