Signal Transduction Antibodies 2
Anti-AQP10 Antibody (CAB2888)
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- SKU:
- CAB2888
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-AQP10 Antibody |
| Antibody SKU: | CAB2888 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 209-301 of human AQP10 (NP_536354.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:1000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HT-29, A-549, K-562, Mouse stomach |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 209-301 of human AQP10 (NP_536354.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | CGIP LNPA RDLG PRLF TYVA GWGP EVFS AGNG WWWV PVVA PLVG ATVG TATY QLLV ALHH PEGP EPAQ DLVS AQHK ASEL ETPA SAQM LECK L |
| Gene ID: | 89872 |
| Uniprot: | Q96PS8 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 27kDa/31kDa |
| Observed MW: | 35kDa |
| Synonyms: | AQP10, AQPA_HUMAN |
| Background: | This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. |
| UniProt Protein Function: | AQP10: Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol. Belongs to the MIP/aquaporin (TC 1.A.8) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Transporter, aquaporin family; Transporter; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:urea transmembrane transporter activity; water channel activity; glycerol channel activity Biological Process: glycerol transport; cellular water homeostasis; response to toxin; water transport; transmembrane transport |
| NCBI Summary: | This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96PS8 |
| NCBI GenInfo Identifier: | 47117905 |
| NCBI Gene ID: | 89872 |
| NCBI Accession: | Q96PS8.2 |
| UniProt Secondary Accession: | Q96PS8,Q5VYD3, Q5VYD4, Q8NG70, |
| UniProt Related Accession: | Q96PS8 |
| Molecular Weight: | 301 |
| NCBI Full Name: | Aquaporin-10 |
| NCBI Synonym Full Names: | aquaporin 10 |
| NCBI Official Symbol: | AQP10 |
| NCBI Official Synonym Symbols: | AQPA_HUMAN |
| NCBI Protein Information: | aquaporin-10; AQP-10; aquaglyceroporin-10; small intestine aquaporin |
| UniProt Protein Name: | Aquaporin-10 |
| UniProt Synonym Protein Names: | Aquaglyceroporin-10; Small intestine aquaporin |
| Protein Family: | Aquaporin |
| UniProt Gene Name: | AQP10 |
| UniProt Entry Name: | AQP10_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AQP10 antibody (CAB2888) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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