Signal Transduction Antibodies 2

Anti-AQP10 Antibody (CAB2888)

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SKU:
CAB2888
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-AQP10 Antibody
Antibody SKU:CAB2888
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 209-301 of human AQP10 (NP_536354.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:1000
Reactivity:Human, Mouse
Positive Samples:HT-29, A-549, K-562, Mouse stomach
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 209-301 of human AQP10 (NP_536354.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CGIP LNPA RDLG PRLF TYVA GWGP EVFS AGNG WWWV PVVA PLVG ATVG TATY QLLV ALHH PEGP EPAQ DLVS AQHK ASEL ETPA SAQM LECK L
Gene ID:89872
Uniprot:Q96PS8
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:27kDa/31kDa
Observed MW:35kDa
Synonyms:AQP10, AQPA_HUMAN
Background:This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea.
UniProt Protein Function:AQP10: Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol. Belongs to the MIP/aquaporin (TC 1.A.8) family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Transporter, aquaporin family; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:urea transmembrane transporter activity; water channel activity; glycerol channel activity

Biological Process: glycerol transport; cellular water homeostasis; response to toxin; water transport; transmembrane transport

NCBI Summary:This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. [provided by RefSeq, Jul 2008]
UniProt Code:Q96PS8
NCBI GenInfo Identifier:47117905
NCBI Gene ID:89872
NCBI Accession:Q96PS8.2
UniProt Secondary Accession:Q96PS8,Q5VYD3, Q5VYD4, Q8NG70,
UniProt Related Accession:Q96PS8
Molecular Weight:301
NCBI Full Name:Aquaporin-10
NCBI Synonym Full Names:aquaporin 10
NCBI Official Symbol:AQP10  
NCBI Official Synonym Symbols:AQPA_HUMAN  
NCBI Protein Information:aquaporin-10; AQP-10; aquaglyceroporin-10; small intestine aquaporin
UniProt Protein Name:Aquaporin-10
UniProt Synonym Protein Names:Aquaglyceroporin-10; Small intestine aquaporin
Protein Family:Aquaporin
UniProt Gene Name:AQP10  
UniProt Entry Name:AQP10_HUMAN
Anti-AQP10 Antibody (CAB2888)Western blot analysis of extracts of various cell lines, using AQP10 antibody (CAB2888) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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