Cell Biology Antibodies 6

Anti-APPBP2 Antibody (CAB15781)

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SKU:
CAB15781
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-APPBP2 Antibody
Antibody SKU:CAB15781
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 386-585 of human APPBP2 (NP_006371.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A-431, HeLa, Jurkat, Raji, Mouse kidney, Mouse brain, Rat kidney, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 386-585 of human APPBP2 (NP_006371.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LEEI AIDC HNKE TEQR LLQE AHDL HLSS LQLA KKAF GEFN VQTA KHYG NLGR LYQS MRKF KEAE EMHI KAIQ IKEQ LLGQ EDYE VALS VGHL ASLY NYDM NQYE NAEK LYLR SIAI GKKL FGEG YSGL EYDY RGLI KLYN SIGN YEKV FEYH NVLS NWNR LRDR QYSV TDAL EDVS TSPQ STEE VVQS FLIS QNVE GPSC
Gene ID:10513
Uniprot:Q92624
Cellular Location:Cytoplasm, Membrane, Nucleus, Peripheral membrane protein, cytoskeleton
Calculated MW:66kDa
Observed MW:67kDa, 71kDa, 80kDa
Synonyms:APPBP2, APP-BP2, HS.84084, PAT1
Background:The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:APPBP2: May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: cytoplasm; cytoplasmic vesicle membrane; microtubule; microtubule associated complex; nucleus

Molecular Function:microtubule motor activity; protein binding

Biological Process: intracellular protein transport; intracellular transport

NCBI Summary:The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
UniProt Code:Q92624
NCBI GenInfo Identifier:50400598
NCBI Gene ID:10513
NCBI Accession:Q92624.2
UniProt Secondary Accession:Q92624,O95095, Q8WVC9, A8K862,
UniProt Related Accession:Q92624
Molecular Weight:66,853 Da
NCBI Full Name:Amyloid protein-binding protein 2
NCBI Synonym Full Names:amyloid beta precursor protein binding protein 2
NCBI Official Symbol:APPBP2  
NCBI Official Synonym Symbols:PAT1; APP-BP2; HS.84084  
NCBI Protein Information:amyloid protein-binding protein 2
UniProt Protein Name:Amyloid protein-binding protein 2
UniProt Synonym Protein Names:Amyloid beta precursor protein-binding protein 2; APP-BP2; Protein interacting with APP tail 1
Protein Family:Amyloid protein-binding protein
UniProt Gene Name:APPBP2  
UniProt Entry Name:APBP2_HUMAN
Anti-APPBP2 Antibody (CAB15781)Western blot analysis of extracts of various cell lines, using APPBP2 antibody (CAB15781) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 35s.
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