Cell Biology Antibodies 3
Anti-AP3D1 Antibody (CAB13058)
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- SKU:
- CAB13058
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-AP3D1 Antibody |
| Antibody SKU: | CAB13058 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 520-700 of human AP3D1 (NP_003929.4). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | LO2, U-87MG, Mouse kidney, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 520-700 of human AP3D1 (NP_003929.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AVYV QNVV KLYA SILQ QKEQ AGEA EGAQ AVTQ LMVD RLPQ FVQS ADLE VQER ASCI LQLV KHIQ KLQA KDVP VAEE VSAL FAGE LNPV APKA QKKV PVPE GLDL DAWI NEPL SDSE SEDE RPRA VFHE EEQR RPKH RPSE ADEE ELAR RREA RKQE QANN PFYI KSSP SPQK RYQD TPGV E |
| Gene ID: | 8943 |
| Uniprot: | O14617 |
| Cellular Location: | Cytoplasm, Cytoplasmic side, Golgi apparatus membrane, Peripheral membrane protein |
| Calculated MW: | 111kDa/114kDa/125kDa/130kDa/136kDa |
| Observed MW: | 110kDa |
| Synonyms: | AP3D1, ADTD, HPS10, hBLVR |
| Background: | The protein encoded by this gene is a subunit of the AP3 adaptor-like complex, which is not clathrin-associated, but is associated with the golgi region, as well as more peripheral structures. The AP-3 complex facilitates the budding of vesicles from the golgi membrane, and may be directly involved in trafficking to lysosomes. This subunit is implicated in intracellular biogenesis and trafficking of pigment granules, and possibly platelet dense granules and neurotransmitter vesicles. Defects in this gene are a cause of a new type of Hermansky-Pudlak syndrome. |
| UniProt Protein Function: | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. |
| NCBI Summary: | The protein encoded by this gene is a subunit of the AP3 adaptor-like complex, which is not clathrin-associated, but is associated with the golgi region, as well as more peripheral structures. The AP-3 complex facilitates the budding of vesicles from the golgi membrane, and may be directly involved in trafficking to lysosomes. This subunit is implicated in intracellular biogenesis and trafficking of pigment granules, and possibly platelet dense granules and neurotransmitter vesicles. Defects in this gene are a cause of a new type of Hermansky-Pudlak syndrome. [provided by RefSeq, Feb 2017] |
| UniProt Code: | O14617 |
| NCBI GenInfo Identifier: | 387849337 |
| NCBI Gene ID: | 8943 |
| NCBI Accession: | NP_001248755.1 |
| UniProt Secondary Accession: | O14617,O00202, O75262, Q59HF5, Q96G11, Q9H3C6, |
| UniProt Related Accession: | O14617 |
| Molecular Weight: | 136,651 Da |
| NCBI Full Name: | AP-3 complex subunit delta-1 isoform 3 |
| NCBI Synonym Full Names: | adaptor related protein complex 3 subunit delta 1 |
| NCBI Official Symbol: | AP3D1 |
| NCBI Official Synonym Symbols: | ADTD; HPS10; hBLVR |
| NCBI Protein Information: | AP-3 complex subunit delta-1 |
| UniProt Protein Name: | AP-3 complex subunit delta-1 |
| UniProt Synonym Protein Names: | AP-3 complex subunit delta; Adaptor-related protein complex 3 subunit delta-1; Delta-adaptin |
| Protein Family: | AP3-complex |
| UniProt Gene Name: | AP3D1 |
 | Western blot analysis of extracts of various cell lines, using AP3D1 antibody (CAB13058) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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