Signal Transduction Antibodies 1
Anti-ANXA3 Antibody (CAB12379)
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- SKU:
- CAB12379
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-ANXA3 Antibody |
| Antibody SKU: | CAB12379 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human ANXA3 (NP_005130.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | HeLa, A-549, HT-29, HepG2, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human ANXA3 (NP_005130.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MASI WVGH RGTV RDYP DFSP SVDA EAIQ KAIR GIGT DEKM LISI LTER SNAQ RQLI VKEY QAAY GKEL KDDL KGDL SGHF EHLM VALV TPPA VFDA KQLK KSMK GAGT NEDA LIEI LTTR TSRQ MKDI SQAY YTVY KKSL GDDI SSET SGDF RKAL LTLA DGRR DESL KVDE HLAK QDAQ ILYK AGEN RWGT DEDK FTEI LCLR SFPQ LKLT FDEY RNIS QKDI VDSI KGEL SGHF EDLL LAIV NCVR NTPA FLAE RLHR ALKG IGTD EFTL NRIM VSRS EIDL LDIR TEFK KHYG YSLY SAIK SDTS GDYE ITLL KICG GDD |
| Gene ID: | 306 |
| Uniprot: | P12429 |
| Cellular Location: | |
| Calculated MW: | 36kDa |
| Observed MW: | 34kDa |
| Synonyms: | ANXA3, ANX3 |
| Background: | This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1, 2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. |
| UniProt Protein Function: | ANXA3: a calcium/phospholipid-binding protein and inhibitor of phospholipase A2, Possesses anti-coagulant properties. Cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion. |
| UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 4q21.21 Cellular Component: cytoplasm; membrane; phagocytic vesicle membrane; plasma membrane; specific granule Molecular Function:calcium-dependent phospholipid binding; calcium-dependent protein binding Biological Process: defense response to bacterium; neutrophil degranulation; phagocytosis; positive regulation of angiogenesis; positive regulation of transcription factor activity |
| NCBI Summary: | This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P12429 |
| NCBI GenInfo Identifier: | 113954 |
| NCBI Gene ID: | 306 |
| NCBI Accession: | P12429.3 |
| UniProt Secondary Accession: | P12429,Q6LET2, B2R9W6, |
| UniProt Related Accession: | P12429 |
| Molecular Weight: | 36,375 Da |
| NCBI Full Name: | Annexin A3 |
| NCBI Synonym Full Names: | annexin A3 |
| NCBI Official Symbol: | ANXA3 |
| NCBI Official Synonym Symbols: | ANX3 |
| NCBI Protein Information: | annexin A3 |
| UniProt Protein Name: | Annexin A3 |
| UniProt Synonym Protein Names: | 35-alpha calcimedin; Annexin III; Annexin-3; Inositol 1,2-cyclic phosphate 2-phosphohydrolase; Lipocortin III; Placental anticoagulant protein III; PAP-III |
| Protein Family: | Annexin |
| UniProt Gene Name: | ANXA3 |
| UniProt Entry Name: | ANXA3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ANXA3 antibody (CAB12379) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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