Cell Biology Antibodies 11
Anti-ANKS1B Antibody (CAB7820)
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- SKU:
- CAB7820
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ANKS1B Antibody |
| Antibody SKU: | CAB7820 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 261-510 of human ANKS1B (NP_858056.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 261-510 of human ANKS1B (NP_858056.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GFPF SAIH QVHN TGDW GEPS ITLR PPNE ATAS TPVQ YWQH HPEK LIFQ SCDY KAFY LGSM LIKE LRGT ESTQ DACA KMRA NCQK STEQ MKKV PTII LSVS YKGV KFID ATNK NIIA EHEI RNIS CAAQ DPED LSTF AYIT KDLK SNHH YCHV FTAF DVNL AYEI ILTL GQAF EVAY QLAL QARK GGHS STLP ESFE NKPS KPIP KPRV SIRK SVQI DPSE QKTL ANLP WIVE PGQE AKRG INTK YETT IF |
| Gene ID: | 56899 |
| Uniprot: | Q7Z6G8 |
| Cellular Location: | Cajal body, Cell junction, Cell projection, Cytoplasm, Nucleus, dendritic spine, postsynaptic cell membrane, postsynaptic density, synapse |
| Calculated MW: | 28kDa/40-57kDa/85kDa/138kDa |
| Observed MW: | 80kDa |
| Synonyms: | ANKS1B, AIDA, AIDA-1, ANKS2, EB-1, EB1, cajalin-2 |
| Background: | This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. |
| UniProt Protein Function: | AIDA-1b: Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion Chromosomal Location of Human Ortholog: 12q23.1 Molecular Function:ephrin receptor binding |
| NCBI Summary: | This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q7Z6G8 |
| NCBI GenInfo Identifier: | 332278155 |
| NCBI Gene ID: | 56899 |
| NCBI Accession: | Q7Z6G8.2 |
| UniProt Secondary Accession: | Q7Z6G8,Q5XLJ0, Q6IVB5, A5PKY5, A7E259, A8K153, A8MSN4 B4DFP6, B4DH98, F8VPM3, F8VZR9, F8WC27, |
| UniProt Related Accession: | Q7Z6G8 |
| Molecular Weight: | 44,522 Da |
| NCBI Full Name: | Ankyrin repeat and sterile alpha motif domain-containing protein 1B |
| NCBI Synonym Full Names: | ankyrin repeat and sterile alpha motif domain containing 1B |
| NCBI Official Symbol: | ANKS1B |
| NCBI Official Synonym Symbols: | EB1; AIDA; EB-1; ANKS2; AIDA-1; cajalin-2 |
| NCBI Protein Information: | ankyrin repeat and sterile alpha motif domain-containing protein 1B |
| UniProt Protein Name: | Ankyrin repeat and sterile alpha motif domain-containing protein 1B |
| UniProt Synonym Protein Names: | Amyloid-beta protein intracellular domain-associated protein 1; AIDA-1; E2A-PBX1-associated protein; EB-1 |
| Protein Family: | Ankyrin repeat and sterile alpha motif domain-containing protein |
| UniProt Gene Name: | ANKS1B |
| UniProt Entry Name: | ANS1B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ANKS1B antibody (CAB7820) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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