Cardiovascular Antibodies

Anti-ANGPTL4 Antibody (CAB2011)

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SKU:
CAB2011
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cardiovascular

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-ANGPTL4 Antibody
Antibody SKU:CAB2011
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 26-406 of human ANGPTL4 (NP_647475.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse lung, Mouse spleen, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 26-406 of human ANGPTL4 (NP_647475.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GPVQ SKSP RFAS WDEM NVLA HGLL QLGQ GLRE HAER TRSQ LSAL ERRL SACG SACQ GTEG STDL PLAP ESRV DPEV LHSL QTQL KAQN SRIQ QLFH KVAQ QQRH LEKQ HLRI QHLQ SQFG LLDH KHLD HEVA KPAR RKRL PEMA QPVD PAHN VSRL HRLP RDCQ ELFQ VGER QSGL FEIQ PQGS PPFL VNCK MTSD GGWT VIQR RHDG SVDF NRPW EAYK AGFG DPHG EFWL GLEK VHSI TGDR NSRL AVQL RDWD GNAE LLQF SVHL GGED TAYS LQLT APVA GQLG ATTV PPSG LSVP FSTW DQDH DLRR DKNC AKSL SGGW WFGT CSHS NLNG QYFR SIPQ QRQK LKKG IFWK TWRG RYYP LQAT TMLI QPMA AEAA S
Gene ID:51129
Uniprot:Q9BY76
Cellular Location:Secreted, extracellular matrix, extracellular space
Calculated MW:26kDa/40kDa/45kDa
Observed MW:45KDa
Synonyms:ANGPTL4, ARP4, FIAF, HARP, HFARP, NL2, PGAR, TGQTL, UNQ171, pp1158
Background:This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4.
UniProt Protein Function:ANGPTL4: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.
UniProt Protein Details:

Protein type:Inhibitor; Apoptosis; Secreted, signal peptide; Secreted; Extracellular matrix

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region

Molecular Function:enzyme inhibitor activity; protein binding

Biological Process: positive regulation of angiogenesis; response to hypoxia; negative regulation of lipoprotein lipase activity; cellular lipid metabolic process; angiogenesis; cell differentiation; protein homooligomerization; negative regulation of apoptosis

Disease: Plasma Triglyceride Level Quantitative Trait Locus

NCBI Summary:This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]
UniProt Code:Q9BY76
NCBI GenInfo Identifier:25008123
NCBI Gene ID:51129
NCBI Accession:Q9BY76.2
UniProt Secondary Accession:Q9BY76,Q53HQ6, Q53HU1, Q6UXN0, Q9HBV4, Q9NZU4, Q9Y5B3 A8MY84, B4E089, D6W670, F5H0I2,
UniProt Related Accession:Q9BY76
Molecular Weight:26,853 Da
NCBI Full Name:Angiopoietin-related protein 4
NCBI Synonym Full Names:angiopoietin-like 4
NCBI Official Symbol:ANGPTL4  
NCBI Official Synonym Symbols:NL2; ARP4; FIAF; HARP; PGAR; HFARP; TGQTL; UNQ171; pp1158; ANGPTL2  
NCBI Protein Information:angiopoietin-related protein 4; fasting-induced adipose factor; PPARG angiopoietin related protein; hepatic angiopoietin-related protein; hepatic fibrinogen/angiopoietin-related protein; peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein
UniProt Protein Name:Angiopoietin-related protein 4
UniProt Synonym Protein Names:Angiopoietin-like protein 4; Hepatic fibrinogen/angiopoietin-related protein; HFARP
Protein Family:Angiopoietin-related protein
UniProt Gene Name:ANGPTL4  
UniProt Entry Name:ANGL4_HUMAN
Anti-ANGPTL4 Antibody (CAB2011)Western blot analysis of extracts of various cell lines, using ANGPTL4 Rabbit pAb (CAB2011) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-ANGPTL4 Antibody (CAB2011)Immunohistochemistry of paraffin-embedded rat kidney using ANGPTL4 Rabbit pAb (CAB2011) at dilution of 1:100 (40x lens).
Anti-ANGPTL4 Antibody (CAB2011)Immunofluorescence analysis of A-549 cells using ANGPTL4 antibody (CAB2011). Blue: DAPI for nuclear staining.
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system_update_altDatasheetMouse ANGPTL4 Recombinant Protein Angiopoietin-related protein 4?ANGPTL4?is a secreted protein and contains 1 fibrinogen C-terminal domain. The protein may act as a regu