Cardiovascular Antibodies
Anti-ANGPTL3 Antibody (CAB5225)
- SKU:
- CAB5225
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-ANGPTL3 Antibody |
| Antibody SKU: | CAB5225 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ANGPTL3 |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, A375, Mouse lung, Mouse liver, Rat lung, Rat liver |
| Immunogen: | A synthesized peptide derived from human ANGPTL3 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 27329 |
| Uniprot: | Q9Y5C1 |
| Cellular Location: | |
| Calculated MW: | 54kDa |
| Observed MW: | 54KDa |
| Synonyms: | ANG-5, ANGPT5, ANL3, FHBL2 |
| Background: | This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015] |
| UniProt Protein Function: | ANGPTL3: Defects in ANGPTL3 are the cause of familial hypobetalipoproteinemia type 2 (FHBL2); also called combined hypobetalipoproteinemia familial. FHBL2 is a disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Affected individuals present with combined hypolipidemia, consisting of extremely low plasma levels of LDL cholesterol, HDL cholesterol, and triglycerides. |
| UniProt Protein Details: | Protein type:Secreted; Cell adhesion; Inhibitor; Motility/polarity/chemotaxis; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1p31.3 Cellular Component: extracellular space; cell surface Molecular Function:integrin binding; enzyme inhibitor activity; phospholipase inhibitor activity; growth factor activity Biological Process: integrin-mediated signaling pathway; cholesterol metabolic process; phospholipid catabolic process; glycerol metabolic process; cell-matrix adhesion; lipid homeostasis; positive regulation of lipid catabolic process; fatty acid metabolic process; signal transduction; sequestering of lipid; positive regulation of angiogenesis; cholesterol homeostasis; acylglycerol homeostasis; phospholipid metabolic process; artery morphogenesis; negative regulation of lipoprotein lipase activity; positive regulation of cell migration; phospholipid homeostasis Disease: Hypobetalipoproteinemia, Familial, 2 |
| NCBI Summary: | This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015] |
| UniProt Code: | Q9Y5C1 |
| NCBI GenInfo Identifier: | 25008126 |
| NCBI Gene ID: | 27329 |
| NCBI Accession: | Q9Y5C1.1 |
| UniProt Related Accession: | Q9Y5C1 |
| Molecular Weight: | ~ 54kDa |
| NCBI Full Name: | Angiopoietin-related protein 3 |
| NCBI Synonym Full Names: | angiopoietin like 3 |
| NCBI Official Symbol: | ANGPTL3 |
| NCBI Official Synonym Symbols: | ANL3; ANG-5; FHBL2; ANGPT5 |
| NCBI Protein Information: | angiopoietin-related protein 3 |
| UniProt Protein Name: | Angiopoietin-related protein 3 |
| UniProt Synonym Protein Names: | Angiopoietin-5; ANG-5; Angiopoietin-like protein 3 |
| Protein Family: | Angiopoietin-related protein |
| UniProt Gene Name: | ANGPTL3 |
| UniProt Entry Name: | ANGL3_HUMAN |
 | Western blot - ANGPTL3 Rabbit mAb (CAB5225) |
Related Products
Anti-ANGPTL3 Recombinant Rabbit Monoclonal Antibody (HDAB0196)
![ANGPTL3 Monoclonal Antibody [P1D10AT] (CPAB0057)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/58286/63468/angptl3-monoclonal-antibody-p1d10at-cpab0057__06794__57580.1706534959.jpg?c=1 "ANGPTL3 Monoclonal Antibody [P1D10AT] (CPAB0057)")
![ANGPTL3 [PAT23D8AT] (CPAB0087)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/58315/63497/angptl3-pat23d8at-cpab0087__13058__73739.1706534968.jpg?c=1 "ANGPTL3 [PAT23D8AT] (CPAB0087)")
Human ANGPTL3 Recombinant Protein (RPPB0037)
Cytokines Recombinant Proteins