Cell Cycle Antibodies 1
Anti-ANAPC1 Antibody (CAB3484)
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- SKU:
- CAB3484
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-ANAPC1 Antibody |
| Antibody SKU: | CAB3484 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ANAPC1 (NP_073153.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | Jurkat, LO2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ANAPC1 (NP_073153.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSNF YEER TTMI AARD LQEF VPFG RDHC KHHP NALN LQLR QLQP ASEL WSSD GAAG LVGS LQEV TIHE KQKE SWQL RKGV SEIG EDVD YDEE LYVA GNMV IWSK GSKS QALA VYKA FTVD SPVQ QALW CDFI ISQD KSEK AYSS NEVE KCIC ILQS SCIN MHSI EGKD YIAS LPFQ VANV WPTK YGLL FERS ASSH EVPP GSPR EPLP TMFS MLHP LDEI TPLV CKSG SLFG SSRV QYVV DHAM KIVF LN |
| Gene ID: | 64682 |
| Uniprot: | Q9H1A4 |
| Cellular Location: | |
| Calculated MW: | 216kDa |
| Observed MW: | 216kDa |
| Synonyms: | ANAPC1, APC1, MCPR, TSG24 |
| Background: | This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. |
| UniProt Protein Function: | APC1: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC1 family. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 2q12.1 Cellular Component: nucleoplasm; anaphase-promoting complex; cytosol Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle |
| NCBI Summary: | This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q9H1A4 |
| NCBI GenInfo Identifier: | 37537845 |
| NCBI Gene ID: | 64682 |
| NCBI Accession: | Q9H1A4.1 |
| UniProt Secondary Accession: | Q9H1A4,Q2M3H8, Q9BSE6, Q9H8D0, |
| UniProt Related Accession: | Q9H1A4 |
| Molecular Weight: | 1944 |
| NCBI Full Name: | Anaphase-promoting complex subunit 1 |
| NCBI Synonym Full Names: | anaphase promoting complex subunit 1 |
| NCBI Official Symbol: | ANAPC1 |
| NCBI Official Synonym Symbols: | APC1; MCPR; TSG24 |
| NCBI Protein Information: | anaphase-promoting complex subunit 1; cyclosome subunit 1; mitotic checkpoint regulator; testis-specific gene 24 protein; anaphase-promoting complex 1 (meiotic checkpoint regulator) |
| UniProt Protein Name: | Anaphase-promoting complex subunit 1 |
| UniProt Synonym Protein Names: | Cyclosome subunit 1; Mitotic checkpoint regulator; Testis-specific gene 24 protein |
| UniProt Gene Name: | ANAPC1 |
| UniProt Entry Name: | APC1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ANAPC1 antibody (CAB3484) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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