Cell Biology Antibodies 17

Anti-AMHR2 Antibody (CAB8813)

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SKU:
CAB8813
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-AMHR2 Antibody
Antibody SKU:CAB8813
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human AMHR2
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:SKOV3, PC-3, K-562, SGC-7901
Immunogen:A synthesized peptide derived from human AMHR2
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:269
Uniprot:Q16671
Cellular Location:
Calculated MW:55kDa
Observed MW:60KDa
Synonyms:AMHR, MISR2, MISRII, MRII
Background:This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009]
UniProt Protein Function:MISR2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
UniProt Protein Details:

Protein type:Membrane protein, integral; Kinase, protein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; EC 2.7.11.30; TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 12q13

Molecular Function:hormone binding; protein binding; receptor activity

Biological Process: sex differentiation; signal transduction

Disease: Persistent Mullerian Duct Syndrome, Types I And Ii

NCBI Summary:This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009]
UniProt Code:Q16671
NCBI GenInfo Identifier:9087133
NCBI Gene ID:269
NCBI Accession:Q16671.1
UniProt Secondary Accession:Q16671,Q13762, Q647K2, A0AVE1, B9EGB7, E9PGD2, F8W1D2
UniProt Related Accession:Q16671
Molecular Weight:51,827 Da
NCBI Full Name:Anti-Muellerian hormone type-2 receptor
NCBI Synonym Full Names:anti-Mullerian hormone receptor type 2
NCBI Official Symbol:AMHR2  
NCBI Official Synonym Symbols:AMHR; MRII; MISR2; MISRII  
NCBI Protein Information:anti-Muellerian hormone type-2 receptor
UniProt Protein Name:Anti-Muellerian hormone type-2 receptor
UniProt Synonym Protein Names:Anti-Muellerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII
Protein Family:Anti-Muellerian hormone type-2 receptor
UniProt Gene Name:AMHR2  
UniProt Entry Name:AMHR2_HUMAN
Anti-AMHR2 Antibody (CAB8813)Western blot - AMHR2 Rabbit mAb (CAB8813)
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