Name: Anti-AMHR2 Antibody (CAB6523)
Brand: Cell Biology Antibodies 10
SKU: CAB6523
Availability: OutOfStock

Antibody Name:	Anti-AMHR2 Antibody
Antibody SKU:	CAB6523
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 18-149 of human AMHR2 (NP_065434.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	Mouse lung, Rat kidney

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 18-149 of human AMHR2 (NP_065434.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	PPNR RTCV FFEA PGVR GSTK TLGE LLDT GTEL PRAI RCLY SRCC FGIW NLTQ DRAQ VEMQ GCRD SDEP GCES LHCD PSPR AHPS PGST LFTC SCGT DFCN ANYS HLPP PGSP GTPG SQGP QAAP GESI WMAL
Gene ID:	269
Uniprot:	Q16671
Cellular Location:	Membrane, Single-pass type I membrane protein
Calculated MW:	51kDa/52kDa/62kDa
Observed MW:	58-63kDa

Synonyms:

AMHR2, AMHR, MISR2, MISRII, MRII

Background:

This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified.

UniProt Protein Function:	MISR2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
UniProt Protein Details:	Protein type:Membrane protein, integral; Kinase, protein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; EC 2.7.11.30; TKL group; STKR family; Type2 subfamily Chromosomal Location of Human Ortholog: 12q13 Molecular Function:hormone binding; protein binding; receptor activity Biological Process: sex differentiation; signal transduction Disease: Persistent Mullerian Duct Syndrome, Types I And Ii
NCBI Summary:	This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009]
UniProt Code:	Q16671
NCBI GenInfo Identifier:	9087133
NCBI Gene ID:	269
NCBI Accession:	Q16671.1
UniProt Secondary Accession:	Q16671,Q13762, Q647K2, A0AVE1, B9EGB7, E9PGD2, F8W1D2
UniProt Related Accession:	Q16671
Molecular Weight:	51,827 Da
NCBI Full Name:	Anti-Muellerian hormone type-2 receptor
NCBI Synonym Full Names:	anti-Mullerian hormone receptor type 2
NCBI Official Symbol:	AMHR2
NCBI Official Synonym Symbols:	AMHR; MRII; MISR2; MISRII
NCBI Protein Information:	anti-Muellerian hormone type-2 receptor
UniProt Protein Name:	Anti-Muellerian hormone type-2 receptor
UniProt Synonym Protein Names:	Anti-Muellerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII
Protein Family:	Anti-Muellerian hormone type-2 receptor
UniProt Gene Name:	AMHR2
UniProt Entry Name:	AMHR2_HUMAN

Western blot analysis of extracts of various cell lines, using AMHR2 antibody (CAB6523) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

Antibodies

Anti-AMHR2 Antibody (CAB8813)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)