Immunology Antibodies 2
Anti-AMBP Antibody (CAB1846)
- SKU:
- CAB1846
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-AMBP Antibody |
| Antibody SKU: | CAB1846 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-352 of human AMBP (NP_001624.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | CEM, U-251MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-352 of human AMBP (NP_001624.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GPVP TPPD NIQV QENF NISR IYGK WYNL AIGS TCPW LKKI MDRM TVST LVLG EGAT EAEI SMTS TRWR KGVC EETS GAYE KTDT DGKF LYHK SKWN ITME SYVV HTNY DEYA IFLT KKFS RHHG PTIT AKLY GRAP QLRE TLLQ DFRV VAQG VGIP EDSI FTMA DRGE CVPG EQEP EPIL IPRV RRAV LPQE EEGS GGGQ LVTE VTKK EDSC QLGY SAGP CMGM TSRY FYNG TSMA CETF QYGG CMGN GNNF VTEK ECLQ TCRT VAAC NLPI VRGP CRAF IQLW AFDA VKGK CVLF PYGG CQGN GNKF YSEK ECRE YCGV PGDG DEEL LRFS N |
| Gene ID: | 259 |
| Uniprot: | P02760 |
| Cellular Location: | Secreted |
| Calculated MW: | 38kDa |
| Observed MW: | 46kDa |
| Synonyms: | AMBP, A1M, EDC1, HCP, HI30, IATIL, ITI, ITIL, ITILC, UTI |
| Background: | This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. |
| UniProt Protein Function: | AMBP: Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 9q32-q33 Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; plasma membrane; extracellular region Molecular Function:serine-type endopeptidase inhibitor activity; protein binding; protein homodimerization activity; calcium oxalate binding; IgA binding; heme binding; calcium channel inhibitor activity Biological Process: negative regulation of JNK cascade; receptor-mediated endocytosis; viral reproduction; heme catabolic process; negative regulation of immune response; protein catabolic process; female pregnancy; cell adhesion; protein-chromophore linkage |
| NCBI Summary: | This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P02760 |
| NCBI GenInfo Identifier: | 122801 |
| NCBI Gene ID: | 259 |
| NCBI Accession: | P02760.1 |
| UniProt Related Accession: | P02760 |
| Molecular Weight: | |
| NCBI Full Name: | Protein AMBP |
| NCBI Synonym Full Names: | alpha-1-microglobulin/bikunin precursor |
| NCBI Official Symbol: | AMBP |
| NCBI Official Synonym Symbols: | A1M; HCP; ITI; UTI; EDC1; HI30; ITIL; IATIL; ITILC |
| NCBI Protein Information: | protein AMBP |
| UniProt Protein Name: | Protein AMBP |
| UniProt Synonym Protein Names: | Alpha-1 microglycoprotein; Complex-forming glycoprotein heterogeneous in charge |
| Protein Family: | Alpha-1-macroglobulin |
| UniProt Gene Name: | AMBP |
| UniProt Entry Name: | AMBP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AMBP antibody (CAB1846) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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