Epigenetics & Nuclear Signaling Antibodies 3

Anti-ALX4 Antibody (CAB2834)

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SKU:
CAB2834
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-ALX4 Antibody
Antibody SKU:CAB2834
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ALX4 (NP_068745.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ALX4 (NP_068745.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNAE TCVS YCES PAAA MDAY YSPV SQSR EGSS PFRA FPGG DKFG TTFL SAAA KAQG FGDA KSRA RYGA GQQD LATP LESG AGAR GSFN KFQP QPST PQPQ PPPQ PQPQ QQQP QPQP PAQP HLYL QRGA CKTP PDGS LKLQ EGSS GHSA ALQV PCYA KESS LGEP ELPP DSDT VGMD SSYL SVKE AGVK GPQD RASS DLPS PLEK ADSE SNKG KKRR NRTT
Gene ID:60529
Uniprot:Q9H161
Cellular Location:Nucleus
Calculated MW:44kDa
Observed MW:44kDa
Synonyms:ALX4, CRS5, FND2
Background:This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart.
UniProt Code:Q9H161
NCBI GenInfo Identifier:254763249
NCBI Gene ID:
NCBI Accession:Q9H161.2
Molecular Weight:44kDa
NCBI Full Name:Homeobox protein aristaless-like 4
UniProt Protein Name:Homeobox protein aristaless-like 4
Protein Family:Homeobox protein
UniProt Gene Name:ALX4  
UniProt Entry Name:ALX4_HUMAN
Anti-ALX4 Antibody (CAB2834)Western blot analysis of extracts of HepG2 cells, using ALX4 antibody (CAB2834) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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