Alpha Synuclein Antibody (pSer129) is a rabbit polyclonal antibody directed against Alpha Synuclein (pSer129), offered by Assay Genie for research applications. Reported applications include WB, ELISA, ICC/IF and IHC. Reported reactivity: Human, Mouse and Rat. Purified by Peptide Affinity.
Alpha-synuclein (SNCA) is a neuronal protein predominantly expressed in the brain, where it is enriched at presynaptic terminals and plays a key role in synaptic function (1). It is also highly expressed in mitochondria-rich regions such as the olfactory bulb, hippocampus, striatum, and thalamus, suggesting a role in mitochondrial dynamics and neuronal energy metabolism (2). Functionally, alpha-synuclein interacts with tubulin (3), indicating a potential role as a microtubule-associated protein involved in cytoskeletal organization and intracellular transport. It is essential for cognitive development, with SNCA inactivation linked to impaired spatial learning and working memory (4). Pathologically, SNCA aggregates are a major non-Aβ component of amyloid plaques in Alzheimer’s disease and a defining feature of Lewy body inclusions in Parkinson’s disease (PD). PD is characterized by the progressive accumulation of alpha-synuclein and ubiquitin-positive inclusions in vulnerable neurons, contributing to neurodegeneration (5, 6). Critically, phosphorylation of alpha-synuclein at serine 129 (pSer129) is a key post-translational modification associated with disease pathology. Approximately 90% of alpha-synuclein found in Lewy bodies is phosphorylated at Ser129, compared to only a small fraction in the healthy brain (7, 8). This modification is widely used as a biomarker for pathological alpha-synuclein and is a focal point in therapeutic and diagnostic research targeting synucleinopathies. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µl. For research use only; not for diagnostic or therapeutic procedures.
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, ELISA, ICC/IF, IHC
Purification:
Peptide Affinity Purified
Concentration:
0.5mg/mL
Reactivity:
Human, Mouse, Rat
Recommended Dilution:
WB (1:1000); ICC/IF (1:500); optimal dilutions for assays should be determined by the user.
Specificity:
Binds to phosphorylated serine 129 on alpha synuclein. Does not detect unphosphorylated serine 129 alpha synuclein. Detects bands at 100, 75, 45, 15 kDa. Bands above 15 kDa are oligomers.
Guarantee:
12 months from date of dispatch
Immunogen:
Synthetic peptide of Human Alpha Synuclein pSer129 (124-134 aa), conjugated to Keyhole Limpet Haemocyanin (KLH).
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