Metabolism Antibodies 1

Anti-ALDH1L2 Antibody (CAB14455)

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SKU:
CAB14455
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-ALDH1L2 Antibody
Antibody SKU:CAB14455
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 280-480 of human ALDH1L2 (NP_001029345.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse pancreas, Rat pancreas, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 280-480 of human ALDH1L2 (NP_001029345.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EPLE IKGA KKPG LVTK NGLV LFGN DGKA LTVR NLQF EDGK MIPA SQYF STGE TSVV ELTA EEVK VAET IKVI WAGI LSNV PIIE DSTD FFKS GASS MDVA RLVE EIRQ KCGG LQLQ NEDV YMAT KFEG FIQK VVRK LRGE DQEV ELVV DYIS KEVN EIMV KMPY QCFI NGQF TDAD DGKT YDTI NPTD GSTI CKVS YASL A
Gene ID:160428
Uniprot:Q3SY69
Cellular Location:Mitochondrion
Calculated MW:22kDa/57kDa/101kDa
Observed MW:102KDa
Synonyms:ALDH1L2, mtFDH
Background:This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.
UniProt Protein Function:ALDH1L2: a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
UniProt Protein Details:

Protein type:EC 1.5.1.6; Oxidoreductase

Chromosomal Location of Human Ortholog: 12q23.3

Cellular Component: mitochondrion

Molecular Function:4-trimethylammoniobutyraldehyde dehydrogenase activity; aminobutyraldehyde dehydrogenase activity; formyltetrahydrofolate dehydrogenase activity; hydroxymethyl-, formyl- and related transferase activity; methyltransferase activity

Biological Process: 10-formyltetrahydrofolate catabolic process; biosynthetic process; methylation; one-carbon compound metabolic process

NCBI Summary:This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
UniProt Code:Q3SY69
NCBI GenInfo Identifier:238814322
NCBI Gene ID:160428
NCBI Accession:NP_001029345.2
UniProt Secondary Accession:Q3SY69,Q3SY68, Q68D62, Q6AI55, Q8N922,
UniProt Related Accession:Q3SY69
Molecular Weight:57,244 Da
NCBI Full Name:mitochondrial 10-formyltetrahydrofolate dehydrogenase
NCBI Synonym Full Names:aldehyde dehydrogenase 1 family member L2
NCBI Official Symbol:ALDH1L2  
NCBI Official Synonym Symbols:mtFDH  
NCBI Protein Information:mitochondrial 10-formyltetrahydrofolate dehydrogenase
UniProt Protein Name:Mitochondrial 10-formyltetrahydrofolate dehydrogenase
UniProt Synonym Protein Names:Aldehyde dehydrogenase family 1 member L2
Protein Family:Mitochondrial 10-formyltetrahydrofolate dehydrogenase
UniProt Gene Name:ALDH1L2  
UniProt Entry Name:AL1L2_HUMAN
Anti-ALDH1L2 Antibody (CAB14455)Western blot analysis of extracts of various cell lines, using ALDH1L2 antibody (CAB14455) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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