Immunology Antibodies 2
Anti-ALCAM Antibody (CAB2218)
(No reviews yet)
Write a Review
- SKU:
- CAB2218
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-ALCAM Antibody |
| Antibody SKU: | CAB2218 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-180 of human ALCAM (NP_001618.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HepG2, A375, U-87MG, A-549, BT-474, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-180 of human ALCAM (NP_001618.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | WYTV NSAY GDTI IIPC RLDV PQNL MFGK WKYE KPDG SPVF IAFR SSTK KSVQ YDDV PEYK DRLN LSEN YTLS ISNA RISD EKRF VCML VTED NVFE APTI VKVF KQPS KPEI VSKA LFLE TEQL KKLG DCIS EDSY PDGN ITWY RNGK VLHP L |
| Gene ID: | 214 |
| Uniprot: | Q13740 |
| Cellular Location: | Membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 15kDa/33kDa/63kDa/65kDa |
| Observed MW: | 105kDa |
| Synonyms: | ALCAM, CD166, MEMD |
| Background: | This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. |
| UniProt Protein Function: | ALCAM: Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 3q13.1 Cellular Component: focal adhesion; cell soma; axon; integral to membrane; external side of plasma membrane Molecular Function:protein binding; receptor binding Biological Process: axon guidance; motor axon guidance; signal transduction; cell adhesion |
| NCBI Summary: | This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q13740 |
| NCBI GenInfo Identifier: | 118572629 |
| NCBI Gene ID: | 214 |
| NCBI Accession: | Q13740.2 |
| UniProt Secondary Accession: | Q13740,O60892, Q1HGM8, Q1HGM9, Q6PEY4, Q6ZS95, B2RNS3 B4DTU0, |
| UniProt Related Accession: | Q13740 |
| Molecular Weight: | 33,878 Da |
| NCBI Full Name: | CD166 antigen |
| NCBI Synonym Full Names: | activated leukocyte cell adhesion molecule |
| NCBI Official Symbol: | ALCAM |
| NCBI Official Synonym Symbols: | MEMD; CD166 |
| NCBI Protein Information: | CD166 antigen |
| UniProt Protein Name: | CD166 antigen |
| UniProt Synonym Protein Names: | Activated leukocyte cell adhesion molecule; CD_antigen: CD166 |
| Protein Family: | CD166 antigen |
| UniProt Gene Name: | ALCAM |
| UniProt Entry Name: | CD166_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ALCAM antibody (CAB2218) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Western blot analysis of extracts of Mouse liver, using ALCAM antibody (CAB2218) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
View AllClose
Related Products
Anti-CD166/ALCAM Antibody (CAB9727)
OverviewProduct Name:CD166/ALCAM Rabbit mAbProduct Code:CAB9727Size:20uL, 50uL, 100uLSynonyms:CD166, MEMDApplications:
Anti-Human CD166 (ALCAM) In Vivo Antibody - Low Endotoxin
OverviewProduct Name:Anti-Human CD166 (ALCAM) In Vivo Antibody - Low EndotoxinProduct Code:IVMB0248Size:1 mg, 5 mg, 25 mg, 50 mg, 100 mgClon
Anti-Human CD166 (ALCAM) In Vivo Antibody - Ultra Low Endotoxin
OverviewProduct Name:Anti-Human CD166 (ALCAM) In Vivo Antibody - Ultra Low EndotoxinProduct Code:IVMB0249Size:1 mg, 5 mg, 25 mg, 50 mg, 100 mg
CD166/ALCAM Monoclonal Antibody
OverviewProduct Name:CD166/ALCAM Monoclonal AntibodyProduct Code:CAB23441Reactivity:Human, Mouse, RatApplications:Western blottin
ESRα Monoclonal Antibody (CAB22181)
OverviewProduct Name:ESRα Monoclonal AntibodyProduct Code:CAB22181Reactivity:Mouse, RatApplications:Immunofluorescence<