Metabolism Antibodies 3

Anti-ALAS1 Antibody (CAB4817)

(No reviews yet) Write a Review
SKU:
CAB4817
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ALAS
Synonyms:
ALAS-H
Synonyms:
ALAS3
Synonyms:
ALASH
Synonyms:
MIG4
Research Area:
Metabolism

Description

Product Name:ALAS1 Rabbit mAb
Product Code:CAB4817
Size:20uL, 50uL, 100uL
Synonyms:ALAS, ALAS-H, ALAS3, ALASH, MIG4
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ALAS1
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HT-29, HepG2, SKOV3
Immunogen:A synthesized peptide derived from human ALAS1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:211
Uniprot:P13196
Calculated MW:71kDa
Observed MW:70KDa
UniProt Protein Function:ALAS1: the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
UniProt Protein Details:

Protein type:EC 2.3.1.37; Amino Acid Metabolism - glycine, serine and threonine; Mitochondrial; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Transferase

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; cytoplasm

Molecular Function:5-aminolevulinate synthase activity; pyridoxal phosphate binding

Biological Process: mitochondrion organization and biogenesis; organelle organization and biogenesis; porphyrin metabolic process; cellular lipid metabolic process; protoporphyrinogen IX biosynthetic process; heme biosynthetic process

NCBI Summary:This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
UniProt Code:P13196
NCBI GenInfo Identifier:122824
NCBI Gene ID:211
NCBI Accession:P13196.2
UniProt Related Accession:P13196
Molecular Weight:640
NCBI Full Name:5-aminolevulinate synthase, nonspecific, mitochondrial
NCBI Synonym Full Names:5'-aminolevulinate synthase 1
NCBI Official Symbol:ALAS1  
NCBI Official Synonym Symbols:ALAS; MIG4; ALAS3; ALASH  
NCBI Protein Information:5-aminolevulinate synthase, nonspecific, mitochondrial; ALAS-H; delta-ALA synthase 1; migration-inducing protein 4; 5-aminolevulinic acid synthase 1; delta-aminolevulinate synthase 1; aminolevulinate, delta-, synthase 1
UniProt Protein Name:5-aminolevulinate synthase, nonspecific, mitochondrial
UniProt Synonym Protein Names:5-aminolevulinic acid synthase 1; Delta-ALA synthase 1; Delta-aminolevulinate synthase 1
Protein Family:Alanine--tRNA ligase
UniProt Gene Name:ALAS1  
UniProt Entry Name:HEM1_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products