Cell Biology Antibodies 4
Anti-AKR1B1 Antibody (CAB13944)
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- SKU:
- CAB13944
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-AKR1B1 Antibody |
| Antibody SKU: | CAB13944 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-316 of human AKR1B1 (NP_001619.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Jurkat, 293T, A375, HepG2, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-316 of human AKR1B1 (NP_001619.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MASR LLLN NGAK MPIL GLGT WKSP PGQV TEAV KVAI DVGY RHID CAHV YQNE NEVG VAIQ EKLR EQVV KREE LFIV SKLW CTYH EKGL VKGA CQKT LSDL KLDY LDLY LIHW PTGF KPGK EFFP LDES GNVV PSDT NILD TWAA MEEL VDEG LVKA IGIS NFNH LQVE MILN KPGL KYKP AVNQ IECH PYLT QEKL IQYC QSKG IVVT AYSP LGSP DRPW AKPE DPSL LEDP RIKA IAAK HNKT TAQV LIRF PMQR NLVV IPKS VTPE RIAE NFKV FDFE LSSQ DMTT LLSY NRNW RVCA LLSC TSHK DYPF HEEF |
| Gene ID: | 231 |
| Uniprot: | P15121 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 35kDa |
| Observed MW: | 36.5kDa |
| Synonyms: | AKR1B1, ADR, ALDR1, ALR2, AR |
| Background: | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. |
| UniProt Protein Function: | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. |
| NCBI Summary: | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009] |
| UniProt Code: | P15121 |
| NCBI GenInfo Identifier: | 113596 |
| NCBI Gene ID: | 231 |
| NCBI Accession: | P15121.3 |
| UniProt Secondary Accession: | P15121,Q5U031, Q6FGA4, Q6ICP2, Q9BS21, Q9UCI9, B2R8N3 |
| UniProt Related Accession: | P15121 |
| Molecular Weight: | |
| NCBI Full Name: | Aldose reductase |
| NCBI Synonym Full Names: | aldo-keto reductase family 1 member B |
| NCBI Official Symbol: | AKR1B1 |
| NCBI Official Synonym Symbols: | AR; ADR; ALR2; ALDR1 |
| NCBI Protein Information: | aldose reductase |
| UniProt Protein Name: | Aldose reductase |
| UniProt Synonym Protein Names: | Aldehyde reductase; Aldo-keto reductase family 1 member B1 |
| Protein Family: | Aldose reductase |
| UniProt Gene Name: | AKR1B1 |
 | Western blot analysis of extracts of various cell lines, using AKR1B1 antibody (CAB13944) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded rat lung using AKR1B1 Antibody (CAB13944) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using AKR1B1 Antibody (CAB13944) at dilution of 1:100 (40x lens). |
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