Cell Death Antibodies 1
Anti-AIM2 Antibody (CAB3356)
- SKU:
- CAB3356
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-AIM2 Antibody |
| Antibody SKU: | CAB3356 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human AIM2 (NP_004824.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human AIM2 (NP_004824.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MESK YKEI LLLT GLDN ITDE ELDR FKFF LSDE FNIA TGKL HTAN RIQV ATLM IQNA GAVS AVMK TIRI FQKL NYML LAKR LQEE KEKV DKQY KSVT KPKP LSQA EMSP AASA AIRN DVAK QRAA PKVS PHVK PEQK QMVA QQES IREG FQKR CLPV MVLK AKKP FTFE TQEG KQEM FHAT VATE KEFF FVKV FNTL LKDK FIPK RIII IARY YRHS GFLE VNSA SRVL DAES DQKV NVPL NIIR KAGE TPKI NTLQ TQPL |
| Gene ID: | 9447 |
| Uniprot: | O14862 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 38kDa |
| Observed MW: | 47kDa |
| Synonyms: | AIM2, PYHIN4 |
| Background: | AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. |
| UniProt Protein Function: | AIM2: a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. Induced by interferon gamma. Defects in AIM2 may be a cause of microsatellite unstable colon cancers. AIM2 and various NOD-like receptors form multiprotein complexes called inflammasomes, which mediate caspase-1-dependent processing of pro-IL-1beta. |
| UniProt Protein Details: | Protein type:Tumor suppressor Chromosomal Location of Human Ortholog: 1q22 Cellular Component: cytoplasm; nucleus; cytosol Molecular Function:identical protein binding; protein binding; double-stranded DNA binding Biological Process: positive regulation of interleukin-1 beta production; positive regulation of protein oligomerization; tumor necrosis factor-mediated signaling pathway; apoptosis; inhibition of NF-kappaB transcription factor; innate immune response; interleukin-1 beta secretion; immune response; positive regulation of interleukin-1 beta secretion; inflammatory response; positive regulation of defense response to virus by host; activation of innate immune response; activation of NF-kappaB transcription factor |
| NCBI Summary: | AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14862 |
| NCBI GenInfo Identifier: | 5902751 |
| NCBI Gene ID: | 9447 |
| NCBI Accession: | O14862.1 |
| UniProt Secondary Accession: | O14862,Q5T3V9, Q96FG9, A8K7M7, |
| UniProt Related Accession: | O14862 |
| Molecular Weight: | 343 |
| NCBI Full Name: | Interferon-inducible protein AIM2 |
| NCBI Synonym Full Names: | absent in melanoma 2 |
| NCBI Official Symbol: | AIM2 |
| NCBI Official Synonym Symbols: | PYHIN4 |
| NCBI Protein Information: | interferon-inducible protein AIM2 |
| UniProt Protein Name: | Interferon-inducible protein AIM2 |
| UniProt Synonym Protein Names: | Absent in melanoma 2 |
| Protein Family: | Protein |
| UniProt Gene Name: | AIM2 |
| UniProt Entry Name: | AIM2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AIM2 antibody (CAB3356) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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