Cell Death Antibodies 1
Anti-AIFM2 Antibody (CAB12128)
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- SKU:
- CAB12128
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-AIFM2 Antibody |
| Antibody SKU: | CAB12128 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-373 of human AIFM2 (NP_116186.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HepG2, A-549 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-373 of human AIFM2 (NP_116186.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGSQ VSVE SGAL HVVI VGGG FGGI AAAS QLQA LNVP FMLV DMKD SFHH NVAA LRAS VETG FAKK TFIS YSVT FKDN FRQG LVVG IDLK NQMV LLQG GEAL PFSH LILA TGST GPFP GKFN EVSS QQAA IQAY EDMV RQVQ RSRF IVVV GGGS AGVE MAAE IKTE YPEK EVTL IHSQ VALA DKEL LPSV RQEV KEIL LRKG VQLL LSER VSNL EELP LNEY REYI KVQT DKGT EVAT NLVI LCTG IKIN SSAY RKAF ESRL ASSG ALRV NEHL QVEG HSNV YAIG DCAD VRTP KMAY LAGL HANI AVAN IVNS VKQR PLQA YKPG ALTF LLSM GRND GVGQ ISGF YVGR LMVR LTKS RDLF VSTS WKTM RQSP P |
| Gene ID: | 84883 |
| Uniprot: | Q9BRQ8 |
| Cellular Location: | Cytoplasm, Lipid-anchor, Membrane, Mitochondrion outer membrane |
| Calculated MW: | 36kDa/40kDa |
| Observed MW: | 41kDa |
| Synonyms: | AIFM2, AMID, PRG3 |
| Background: | This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. |
| UniProt Protein Function: | AIFM2: Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest. Belongs to the FAD-dependent oxidoreductase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Apoptosis; EC 1.-.-.-; Membrane protein, integral; Mitochondrial; Oxidoreductase Chromosomal Location of Human Ortholog: 10q22.1 Cellular Component: cytoplasm; cytosol; extracellular space; lipid particle; mitochondrial outer membrane; mitochondrion Molecular Function:DNA binding; electron-transferring-flavoprotein dehydrogenase activity; FAD binding Biological Process: apoptotic mitochondrial changes; positive regulation of apoptosis; regulation of apoptosis |
| NCBI Summary: | This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010] |
| UniProt Code: | Q9BRQ8 |
| NCBI GenInfo Identifier: | 74752283 |
| NCBI Gene ID: | 84883 |
| NCBI Accession: | Q9BRQ8.1 |
| UniProt Secondary Accession: | Q9BRQ8,Q63Z39, B3KXI0, |
| UniProt Related Accession: | Q9BRQ8 |
| Molecular Weight: | 41kDa |
| NCBI Full Name: | Apoptosis-inducing factor 2 |
| NCBI Synonym Full Names: | apoptosis inducing factor, mitochondria associated 2 |
| NCBI Official Symbol: | AIFM2 |
| NCBI Official Synonym Symbols: | AMID; PRG3 |
| NCBI Protein Information: | apoptosis-inducing factor 2 |
| UniProt Protein Name: | Apoptosis-inducing factor 2 |
| UniProt Synonym Protein Names: | Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; Apoptosis-inducing factor-like mitochondrion-associated inducer of death; p53-responsive gene 3 protein |
| Protein Family: | Apoptosis-inducing factor |
| UniProt Gene Name: | AIFM2 |
 | Western blot analysis of extracts of various cell lines, using AIFM2 antibody (CAB12128) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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