Cell Biology Antibodies 4

Anti-AGTR1 Antibody (CAB14201)

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SKU:
CAB14201
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-AGTR1 Antibody
Antibody SKU:CAB14201
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 250-350 of human AGTR1 (NP_000676.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse liver, Rat liver
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 250-350 of human AGTR1 (NP_000676.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FFSW IPHQ IFTF LDVL IQLG IIRD CRIA DIVD TAMP ITIC IAYF NNCL NPLF YGFL GKKF KRYF LQLL KYIP PKAK SHSN LSTK MSTL SYRP SDNV SSST K
Gene ID:185
Uniprot:P30556
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:41kDa
Observed MW:45KDa
Synonyms:AGTR1, AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R
Background:Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.
UniProt Protein Function:AT1: receptor for angiotensin II. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. Mediates the major cardiovascular effects of angiotensin II. May play role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
UniProt Protein Details:

Protein type:Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3q24

Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function:protein binding; angiotensin type II receptor activity; protein heterodimerization activity; angiotensin type I receptor activity; bradykinin receptor binding

Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of vasodilation; positive regulation of cellular protein metabolic process; renin-angiotensin regulation of aldosterone production; calcium-mediated signaling; regulation of systemic arterial blood pressure by renin-angiotensin; Rho protein signal transduction; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; renin-angiotensin regulation of blood vessel size; regulation of vasoconstriction; regulation of inflammatory response; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of cell growth; kidney development; positive regulation of phospholipase A2 activity; positive regulation of inflammatory response; positive regulation of NAD(P)H oxidase activity

Disease: Renal Tubular Dysgenesis; Hypertension, Essential

NCBI Summary:Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
UniProt Code:P30556
NCBI GenInfo Identifier:231519
NCBI Gene ID:185
NCBI Accession:P30556.1
UniProt Secondary Accession:P30556,Q13725, Q8TBK4,
UniProt Related Accession:P30556
Molecular Weight:41kDa
NCBI Full Name:Type-1 angiotensin II receptor
NCBI Synonym Full Names:angiotensin II receptor, type 1
NCBI Official Symbol:AGTR1  
NCBI Official Synonym Symbols:AT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1B  
NCBI Protein Information:type-1 angiotensin II receptor; type-1B angiotensin II receptor
UniProt Protein Name:Type-1 angiotensin II receptor
UniProt Synonym Protein Names:AT1AR; AT1BR; Angiotensin II type-1 receptor; AT1
Protein Family:Type-1 angiotensin II receptor
UniProt Gene Name:AGTR1  
UniProt Entry Name:AGTR1_HUMAN
Anti-AGTR1 Antibody (CAB14201)Western blot analysis of extracts of various cell lines, using AGTR1 antibody (CAB14201) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
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