Metabolism Antibodies 1

Anti-AGPS Antibody (CAB10484)

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SKU:
CAB10484
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-AGPS Antibody
Antibody SKU:CAB10484
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 379-658 of human AGPS (NP_003650.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HL-60, HeLa, HepG2, K-562, Mouse kidney, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 379-658 of human AGPS (NP_003650.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IKIR PVPE YQKY GSVA FPNF EQGV ACLR EIAK QRCA PASI RLMD NKQF QFGH ALKP QVSS IFTS FLDG LKKF YITK FKGF DPNQ LSVA TLLF EGDR EKVL QHEK QVYD IAAK FGGL AAGE DNGQ RGYL LTYV IAYI RDLA LEYY VLGE SFET SAPW DRVV DLCR NVKE RITR ECKE KGVQ FAPF STCR VTQT YDAG ACIY FYFA FNYR GISD PLTV FEQT EAAA REEI LANG GSLS HHHG VGKL RKQW LKES ISDV GFGM LKSV KEYV DPNN IFGN RNLL
Gene ID:8540
Uniprot:O00116
Cellular Location:Peroxisome membrane
Calculated MW:72kDa
Observed MW:60-73kDa
Synonyms:AGPS, ADAP-S, ADAS, ADHAPS, ADPS, ALDHPSY, RCDP3
Background:This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome.
UniProt Protein Function:AGPS: Defects in AGPS are the cause of rhizomelic chondrodysplasia punctata type 3 (RCDP3). RCDP3 is characterized by rhizomelic shortening of femur and humerus, vertebral disorders, cataract, cutaneous lesions and severe mental retardation. Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
UniProt Protein Details:

Protein type:EC 2.5.1.26; Lipid Metabolism - ether lipid; Mitochondrial; Oxidoreductase; Transferase

Chromosomal Location of Human Ortholog: 2q31.2

Cellular Component: membrane; mitochondrion; nucleolus; peroxisomal matrix; peroxisomal membrane; peroxisome

Molecular Function:alkylglycerone-phosphate synthase activity; protein binding

Biological Process: ether lipid biosynthetic process; lipid biosynthetic process

Disease: Rhizomelic Chondrodysplasia Punctata, Type 3

NCBI Summary:This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008]
UniProt Code:O00116
NCBI GenInfo Identifier:2498106
NCBI Gene ID:8540
NCBI Accession:O00116.1
UniProt Secondary Accession:O00116,Q2TU35, A5D8U9,
UniProt Related Accession:O00116
Molecular Weight:73kDa
NCBI Full Name:Alkyldihydroxyacetonephosphate synthase, peroxisomal
NCBI Synonym Full Names:alkylglycerone phosphate synthase
NCBI Official Symbol:AGPS  
NCBI Official Synonym Symbols:ADAS; ADPS; RCDP3; ADAP-S; ADHAPS; ALDHPSY  
NCBI Protein Information:alkyldihydroxyacetonephosphate synthase, peroxisomal
UniProt Protein Name:Alkyldihydroxyacetonephosphate synthase, peroxisomal
UniProt Synonym Protein Names:Aging-associated gene 5 protein; Alkylglycerone-phosphate synthase
Protein Family:Alkyldihydroxyacetonephosphate synthase
UniProt Gene Name:AGPS  
Anti-AGPS Antibody (CAB10484)Western blot analysis of extracts of various cell lines, using AGPS antibody (CAB10484) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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