Epigenetics & Nuclear Signaling Antibodies 3

Anti-AFF4 Antibody (CAB4644)

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SKU:
CAB4644
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
AFF4
Synonyms:
AF5Q31
Synonyms:
CHOPS
Synonyms:
MCEF
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:AFF4 Rabbit pAb
Product Code:CAB4644
Size:20uL, 50uL, 100uL
Synonyms:AFF4, AF5Q31, CHOPS, MCEF
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human AFF4 (NP_055238.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:U-87MG, HeLa, 293T, LO2, MCF7, Mouse pancreas
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human AFF4 (NP_055238.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNRE DRNV LRMK ERER RNQE IQQG EDAF PPSS PLFA EPYK VTSK EDKL SSRI QSML GNYD EMKD FIGD RSIP KLVA IPKP TVPP SADE KSNP NFFE QRHG GSHQ SSKW TPVG PAPS TSQS QKRS SGLQ SGHS SQRT SAGS SSGT NSSG QRHD RESY NNSG SSSR KKGQ HGSE HSKS RSSS PGKP QAVS SLNS SHSR SHGN DHHS KEHQ RSKS PRDP DANW
Gene ID:27125
Uniprot:Q9UHB7
Cellular Location:Nucleus
Calculated MW:38kDa/98kDa/127kDa
Observed MW:150kDa
UniProt Protein Function:MCEF: a putative transcription factor. Component of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor b (P-TEFb). Genetic fusion of its gene with MLL has been observed in a subset of acute lymphoblastic leukemia patients. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: nucleoplasm; transcription elongation factor complex; mitochondrion; nucleolus; nucleus

Molecular Function:protein binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; spermatid development

Disease: Chops Syndrome

NCBI Summary:The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011]
UniProt Code:Q9UHB7
NCBI GenInfo Identifier:74720814
NCBI Gene ID:27125
NCBI Accession:Q9UHB7.1
UniProt Related Accession:Q9UHB7
Molecular Weight:
NCBI Full Name:AF4/FMR2 family member 4
NCBI Synonym Full Names:AF4/FMR2 family member 4
NCBI Official Symbol:AFF4  
NCBI Official Synonym Symbols:MCEF; CHOPS; AF5Q31  
NCBI Protein Information:AF4/FMR2 family member 4
UniProt Protein Name:AF4/FMR2 family member 4
UniProt Synonym Protein Names:ALL1-fused gene from chromosome 5q31 protein; Protein AF-5q31; Major CDK9 elongation factor-associated protein
Protein Family:AF4/FMR2 family
UniProt Gene Name:AFF4  
UniProt Entry Name:AFF4_HUMAN
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