Cell Death Antibodies 1
Anti-AEN Antibody (CAB15182)
- SKU:
- CAB15182
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-AEN Antibody |
| Antibody SKU: | CAB15182 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human AEN (NP_073604.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human AEN (NP_073604.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVPR EAPE SAQC LCPS LTIP NAKD VLRK RHKR RSRQ HQRF MARK ALLQ EQGL LSMP PEPG SSPL PTPF GAAT ATEA ASSG KQCL RAGS GSAP CSRR PAPG KASG PLPS KCVA IDCE MVGT GPRG RVSE LARC SIVS YHGN VLYD KYIR PEMP IADY RTRW SGIT RQHM RKAV PFQV AQKE ILKL LKGK VVVG HALH NDFQ ALKY VHPR SQTR DTTY VPNF LSEP GLHT RARV SLKD LALQ LLHK KIQV GQHG HSSV EDAT TAME LYRL VEVQ WEQQ EARS LWTC PEDR EPDS STDM EQYM EDQY WPDD LAHG SRGG AREA QDRR N |
| Gene ID: | 64782 |
| Uniprot: | Q8WTP8 |
| Cellular Location: | Nucleus, nucleolus |
| Calculated MW: | 36kDa |
| Observed MW: | Refer to figures |
| Synonyms: | AEN, ISG20L1, pp12744 |
| Background: |
| UniProt Protein Function: | AEN: Exonuclease with activity against single- and double- stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.-.-; Hydrolase; Nucleolus; Apoptosis Chromosomal Location of Human Ortholog: 15q26.1 Cellular Component: nucleoplasm; nuclear membrane; nucleolus; nucleus Molecular Function:nucleic acid binding; exonuclease activity Biological Process: response to ionizing radiation; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis |
| UniProt Code: | Q8WTP8 |
| NCBI GenInfo Identifier: | 194239666 |
| NCBI Gene ID: | 64782 |
| NCBI Accession: | NP_073604.3 |
| UniProt Secondary Accession: | Q8WTP8,Q9BSA5, Q9H9X7, C9J571, |
| UniProt Related Accession: | Q8WTP8 |
| Molecular Weight: | 36,496 Da |
| NCBI Full Name: | apoptosis-enhancing nuclease |
| NCBI Synonym Full Names: | apoptosis enhancing nuclease |
| NCBI Official Symbol: | AEN |
| NCBI Official Synonym Symbols: | ISG20L1; pp12744 |
| NCBI Protein Information: | apoptosis-enhancing nuclease; interferon-stimulated 20 kDa exonuclease-like 1; interferon stimulated exonuclease gene 20kDa-like 1 |
| UniProt Protein Name: | Apoptosis-enhancing nuclease |
| UniProt Synonym Protein Names: | Interferon-stimulated 20 kDa exonuclease-like 1 |
| Protein Family: | Apoptosis-enhancing nuclease |
| UniProt Gene Name: | AEN |
| UniProt Entry Name: | AEN_HUMAN |
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