Epigenetics & Nuclear Signaling Antibodies 4
Anti-AEBP2 Antibody (CAB7400)
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- SKU:
- CAB7400
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-AEBP2 Antibody |
| Antibody SKU: | CAB7400 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 234-503 of human AEBP2 (NP_694939.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, 293T, A-549, Mouse kidney, Mouse skeletal muscle, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 234-503 of human AEBP2 (NP_694939.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | STIS SGRS TPAM MNGQ GSTT SSSK NIAY NCCW DQCQ ACFN SSPD LADH IRSI HVDG QRGG VFVC LWKG CKVY NTPS TSQS WLQR HMLT HSGD KPFK CVVG GCNA SFAS QGGL ARHV PTHF SQQN SSKV SSQP KAKE ESPS KAGM NKRR KLKN KRRR SLPR PHDF FDAQ TLDA IRHR AICF NLSA HIES LGKG HSVV FHST VIAK RKED SGKI KLLL HWMP EDIL PDVW VNES ERHQ LKTK VVHL SKLP KDTA LLLD PNIY RTMP QKRL KR |
| Gene ID: | 121536 |
| Uniprot: | Q6ZN18 |
| Cellular Location: | Nucleus |
| Calculated MW: | 33kDa/52kDa/54kDa |
| Observed MW: | 54kDa |
| Synonyms: | AEBP2 |
| Background: |
| UniProt Protein Function: | AEBP2: DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3. Belongs to the AEBP2/jing C2H2-type zinc-finger family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; Transcription, coactivator/corepressor; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 12p12.3 Cellular Component: nucleoplasm; ESC/E(Z) complex Molecular Function:metal ion binding; transcription corepressor activity Biological Process: transcription, DNA-dependent; negative regulation of gene expression, epigenetic; gene expression; negative regulation of transcription from RNA polymerase II promoter; chromatin modification; regulation of gene expression, epigenetic |
| UniProt Code: | Q6ZN18 |
| NCBI GenInfo Identifier: | 190358163 |
| NCBI Gene ID: | 121536 |
| NCBI Accession: | Q6ZN18.2 |
| UniProt Secondary Accession: | Q6ZN18,Q59FS5, Q6ZN62, Q96BG3, |
| UniProt Related Accession: | Q6ZN18 |
| Molecular Weight: | 517 |
| NCBI Full Name: | Zinc finger protein AEBP2 |
| NCBI Synonym Full Names: | AE binding protein 2 |
| NCBI Official Symbol: | AEBP2 |
| NCBI Protein Information: | zinc finger protein AEBP2; AE-binding protein 2; adipocyte enhancer-binding protein 2; AE(adipocyte enhancer)-binding protein 2 |
| UniProt Protein Name: | Zinc finger protein AEBP2 |
| UniProt Synonym Protein Names: | Adipocyte enhancer-binding protein 2; AE-binding protein 2 |
| Protein Family: | Zinc finger protein |
| UniProt Gene Name: | AEBP2 |
| UniProt Entry Name: | AEBP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AEBP2 antibody (CAB7400) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using AEBP2 antibody (CAB7400) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using AEBP2 antibody (CAB7400) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of A549 cells using AEBP2 antibody (CAB7400). Blue: DAPI for nuclear staining. |
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