Epigenetics & Nuclear Signaling Antibodies 2
Anti-AEBP1 Antibody (CAB16340)
- SKU:
- CAB16340
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Antibody Name: | Anti-AEBP1 Antibody |
Antibody SKU: | CAB16340 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC IF |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 999-1158 of human AEBP1 (NP_001120.3). |
Application: | WB IHC IF |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | Mouse brain |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 999-1158 of human AEBP1 (NP_001120.3). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | NRPI PHID PSRP MTPQ QRRL QQRR LQHR LRLR AQMR LRRL NATT TLGP HTVP PTLP PAPA TTLS TTIE PWGL IPPT TAGW EESE TETY TEVV TEFG TEVE PEFG TKVE PEFE TQLE PEFE TQLE PEFE EEEE EEKE EEIA TGQA FPFT TVET YTVN FGDF |
Gene ID: | 165 |
Uniprot: | Q8IUX7 |
Cellular Location: | Cytoplasm, Nucleus, Secreted |
Calculated MW: | 82kDa/130kDa |
Observed MW: | 131kDa |
Synonyms: | AEBP1, ACLP |
Background: | This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. |
UniProt Protein Function: | AEBP1: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I- kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription factor; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 7p13 Cellular Component: extracellular matrix; extracellular space; cytoplasm; nucleus Molecular Function:calmodulin binding; carboxypeptidase activity; zinc ion binding; transcription factor activity; metallocarboxypeptidase activity; transcription corepressor activity Biological Process: muscle development; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; proteolysis; skeletal development |
NCBI Summary: | This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013] |
UniProt Code: | Q8IUX7 |
NCBI GenInfo Identifier: | 119581523 |
NCBI Gene ID: | 165 |
NCBI Accession: | EAW61119.1 |
UniProt Secondary Accession: | Q8IUX7,Q14113, Q59ER7, Q6ZSC7, Q7KZ79, |
UniProt Related Accession: | Q8IUX7 |
Molecular Weight: | 82,183 Da |
NCBI Full Name: | AE binding protein 1 |
NCBI Synonym Full Names: | AE binding protein 1 |
NCBI Official Symbol: | AEBP1 |
NCBI Official Synonym Symbols: | ACLP |
NCBI Protein Information: | adipocyte enhancer-binding protein 1 |
UniProt Protein Name: | Adipocyte enhancer-binding protein 1 |
UniProt Synonym Protein Names: | Aortic carboxypeptidase-like protein |
Protein Family: | Adipocyte enhancer-binding protein |
UniProt Gene Name: | AEBP1 |
UniProt Entry Name: | AEBP1_HUMAN |
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