Cell Biology Antibodies 8
Anti-ADRB2 Antibody (CAB2048)
- SKU:
- CAB2048
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ADRB2 Antibody |
| Antibody SKU: | CAB2048 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 334-413 of human ADRB2 (NP_000015.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, HepG2, Mouse heart, Mouse liver, Rat heart, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 334-413 of human ADRB2 (NP_000015.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IAFQ ELLC LRRS SLKA YGNG YSSN GNTG EQSG YHVE QEKE NKLL CEDL PGTE DFVG HQGT VPSD NIDS QGRN CSTN DSLL |
| Gene ID: | 154 |
| Uniprot: | P07550 |
| Cellular Location: | Cell membrane, Early endosome, Multi-pass membrane protein |
| Calculated MW: | 46kDa |
| Observed MW: | 53-65kDa |
| Synonyms: | ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR |
| Background: | This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. |
| UniProt Protein Function: | ADRB2: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral Chromosomal Location of Human Ortholog: 5q31-q32 Cellular Component: lysosome; integral to plasma membrane; apical plasma membrane; plasma membrane; nucleus; receptor complex; endosome Molecular Function:protein binding; protein homodimerization activity; potassium channel regulator activity; beta2-adrenergic receptor activity; norepinephrine binding; adenylate cyclase binding Biological Process: arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; receptor-mediated endocytosis; diet induced thermogenesis; transmembrane receptor protein tyrosine kinase activation (dimerization); negative regulation of multicellular organism growth; regulation of vasodilation; adenylate cyclase activation; regulation of sodium ion transport; positive regulation of bone mineralization; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; cell surface receptor linked signal transduction; positive regulation of MAPKKK cascade; positive regulation of protein ubiquitination; heat generation; negative regulation of smooth muscle contraction; brown fat cell differentiation; endosome to lysosome transport; positive regulation of transcription from RNA polymerase II promoter; response to cold; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; bone resorption Disease: Obesity; Asthma, Susceptibility To |
| NCBI Summary: | This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P07550 |
| NCBI GenInfo Identifier: | 296439450 |
| NCBI Gene ID: | 154 |
| NCBI Accession: | P07550.3 |
| UniProt Secondary Accession: | P07550,O14823, O14824, O14825, O14826, Q4JG18, Q53GA6 Q6GMT4, Q6P4D8, Q8NEQ9, B0LPE4, B2R7X2, |
| UniProt Related Accession: | P07550 |
| Molecular Weight: | 46,459 Da |
| NCBI Full Name: | Beta-2 adrenergic receptor |
| NCBI Synonym Full Names: | adrenoceptor beta 2, surface |
| NCBI Official Symbol: | ADRB2 |
| NCBI Official Synonym Symbols: | BAR; B2AR; ADRBR; ADRB2R; BETA2AR |
| NCBI Protein Information: | beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; catecholamine receptor; adrenergic, beta-2-, receptor, surface |
| UniProt Protein Name: | Beta-2 adrenergic receptor |
| UniProt Synonym Protein Names: | Beta-2 adrenoreceptor |
| Protein Family: | Beta-2 adrenergic receptor |
| UniProt Gene Name: | ADRB2 |
| UniProt Entry Name: | ADRB2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ADRB2 antibody (CAB2048) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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