Epigenetics & Nuclear Signaling Antibodies 3

Anti-ADNP Antibody (CAB4546)

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SKU:
CAB4546
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ADNP
Synonyms:
ADNP1
Synonyms:
HVDAS
Synonyms:
MRD28
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:ADNP Rabbit pAb
Product Code:CAB4546
Size:20uL, 50uL, 100uL
Synonyms:ADNP, ADNP1, HVDAS, MRD28
Applications:WB, IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 843-1102 of human ADNP (NP_056154.1).
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse
Positive Samples:293T, U-87MG, HT-29, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 843-1102 of human ADNP (NP_056154.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EWLF ENHD EKDS RVNA SKTA DKKL NLGK EDDS SSDS FENL EEES NESG SPFD PVFE VEPK ISND NPEE HVLK VIPE DASE SEEK LDQK EDGS KYET IHLT EEPT KLMH NASD SEVD QDDV VEWK DGAS PSES GPGS QQVS DFED NTCE MKPG TWSD ESSQ SEDA RSSK PAAK KKAT MQGD REQL KWKN SSYG KVEG FWSK DQSQ WKNA SEND ERLS NPQI EWQN STID SEDG EQFD NMTD GVAE PMHG SLAG VKLS SQQA
Gene ID:23394
Uniprot:Q9H2P0
Cellular Location:Nucleus
Calculated MW:123kDa
Observed MW:163kDa
UniProt Protein Function:ADNP: Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.
UniProt Protein Details:

Protein type:DNA-binding; C2H2-type zinc finger protein; Apoptosis

Chromosomal Location of Human Ortholog: 20q13.13

Cellular Component: extracellular space; nucleus

Molecular Function:protein binding; DNA binding; metal ion binding; chromatin binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; negative regulation of neuron apoptosis

Disease: Mental Retardation, Autosomal Dominant 28

NCBI Summary:Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
UniProt Code:Q9H2P0
NCBI GenInfo Identifier:24636245
NCBI Gene ID:23394
NCBI Accession:Q9H2P0.1
UniProt Secondary Accession:Q9H2P0,O94881, Q5BKU2, Q9UG34, E1P5Y2,
UniProt Related Accession:Q9H2P0
Molecular Weight:1102
NCBI Full Name:Activity-dependent neuroprotector homeobox protein
NCBI Synonym Full Names:activity-dependent neuroprotector homeobox
NCBI Official Symbol:ADNP  
NCBI Official Synonym Symbols:ADNP1; MRD28  
NCBI Protein Information:activity-dependent neuroprotector homeobox protein; ADNP homeobox 1; activity-dependent neuroprotective protein
UniProt Protein Name:Activity-dependent neuroprotector homeobox protein
UniProt Synonym Protein Names:Activity-dependent neuroprotective protein
Protein Family:ADNP homeobox protein
UniProt Gene Name:ADNP  
UniProt Entry Name:ADNP_HUMAN
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