Metabolism Antibodies 1

Anti-ADIPOR2 Antibody (CAB12777)

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SKU:
CAB12777
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-ADIPOR2 Antibody
Antibody SKU:CAB12777
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human ADIPOR2 (NP_078827.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, HeLa, Mouse liver, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human ADIPOR2 (NP_078827.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNEP TENR LGCS RTPE PDIR LRKG HQLD GTRR GDND SHQG DLEP ILEA SVLS SHHK KSSE EHEY SDEA PQED EGFM GMSP
Gene ID:79602
Uniprot:Q86V24
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:43kDa
Observed MW:44kDa
Synonyms:ADIPOR2, ACDCR2, PAQR2
Background:
UniProt Protein Function:ADIPOR2: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin. Belongs to the ADIPOR family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: integral to membrane; plasma membrane

Molecular Function:adiponectin binding; identical protein binding; hormone binding; protein heterodimerization activity; receptor activity

Biological Process: positive regulation of glucose import; hormone-mediated signaling; heart development; adiponectin-mediated signaling pathway; fatty acid oxidation; female pregnancy; negative regulation of cell growth; response to nutrient

NCBI Summary:The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]
UniProt Code:Q86V24
NCBI GenInfo Identifier:38372190
NCBI Gene ID:79602
NCBI Accession:Q86V24.1
UniProt Related Accession:Q86V24
Molecular Weight:43kDa
NCBI Full Name:Adiponectin receptor protein 2
NCBI Synonym Full Names:adiponectin receptor 2
NCBI Official Symbol:ADIPOR2  
NCBI Official Synonym Symbols:PAQR2; ACDCR2  
NCBI Protein Information:adiponectin receptor protein 2
UniProt Protein Name:Adiponectin receptor protein 2
UniProt Synonym Protein Names:Progestin and adipoQ receptor family member II
Protein Family:Adiponectin receptor protein
UniProt Gene Name:ADIPOR2  
UniProt Entry Name:ADR2_HUMAN
Anti-ADIPOR2 Antibody (CAB12777)Western blot analysis of extracts of various cell lines, using ADIPOR2 antibody (CAB12777) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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