KO Validated Antibodies 1

Anti-ADIPOR1 Antibody (CAB18045)[KO Validated]

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SKU:
CAB18045
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-ADIPOR1 Antibody [KO Validated]
Antibody SKU:CAB18045
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-136 of human ADIPOR1 (NP_057083.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-136 of human ADIPOR1 (NP_057083.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSSH KGSV VAQG NGAP ASNR EADT VELA ELGP LLEE KGKR VIAN PPKA EEEQ TCPV PQEE EEEV RVLT LPLQ AHHA MEKM EEFV YKVW EGRW RVIP YDVL PDWL KDND YLLH GHRP PMPS FRAC FKSI FRIH TETG
Gene ID:51094
Uniprot:Q96A54
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:42kDa
Observed MW:43kDa
Anti-ADIPOR1 Antibody [KO Validated] (CAB18045)Western blot analysis of extracts from normal (control) and ADIPOR1 knockout (KO) 293T cells, using ADIPOR1 antibody (CAB18045) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Synonyms:ADIPOR1, ACDCR1, CGI-45, CGI45, PAQR1, TESBP1A
Background:This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene.
UniProt Protein Function:ADIPOR1: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin. Belongs to the ADIPOR family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: membrane; plasma membrane; integral to membrane

Molecular Function:adiponectin binding; identical protein binding; hormone binding; protein heterodimerization activity; receptor activity; protein kinase binding

Biological Process: hormone-mediated signaling; adiponectin-mediated signaling pathway; positive regulation of JAK-STAT cascade; fatty acid oxidation; negative regulation of cell growth; positive regulation of insulin receptor signaling pathway; leptin-mediated signaling pathway

NCBI Summary:This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]
UniProt Code:Q96A54
NCBI GenInfo Identifier:38372248
NCBI Gene ID:51094
NCBI Accession:Q96A54.1
UniProt Secondary Accession:Q96A54,Q53HS7, Q53YY6, Q9Y360, B3KMB0,
UniProt Related Accession:Q96A54
Molecular Weight:375
NCBI Full Name:Adiponectin receptor protein 1
NCBI Synonym Full Names:adiponectin receptor 1
NCBI Official Symbol:ADIPOR1  
NCBI Official Synonym Symbols:CGI45; PAQR1; ACDCR1; CGI-45; TESBP1A  
NCBI Protein Information:adiponectin receptor protein 1; progestin and adipoQ receptor family member I
UniProt Protein Name:Adiponectin receptor protein 1
UniProt Synonym Protein Names:Progestin and adipoQ receptor family member I
Protein Family:Adiponectin receptor protein
UniProt Gene Name:ADIPOR1  
UniProt Entry Name:ADR1_HUMAN
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