Metabolism Antibodies 2

Anti-ADI1 Antibody (CAB4820)

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SKU:
CAB4820
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ADI1
Synonyms:
APL1
Synonyms:
ARD
Synonyms:
Fe-ARD
Synonyms:
HMFT1638
Synonyms:
MTCBP1
Synonyms:
Ni-ARD
Synonyms:
SIPL
Synonyms:
mtnD

Description

Product Name:ADI1 Rabbit pAb
Product Code:CAB4820
Size:20uL, 50uL, 100uL
Synonyms:ADI1, APL1, ARD, Fe-ARD, HMFT1638, MTCBP1, Ni-ARD, SIPL, mtnD
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human ADI1 (NP_060739.2).
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, A-549, SGC-7901, HT-29, 293T, HepG2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human ADI1 (NP_060739.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MVQA WYMD DAPG DPRQ PHRP DPGR PVGL EQLR RLGV LYWK LDAD KYEN DPEL EKIR RERN YSWM DIIT ICKD KLPN YEEK IKMF YEEH LHLD DEIR YILD GSGY FDVR DKED QWIR IFME KGDM VTLP AGIY HRFT VDEK NYTK AMRL FVGE PVWT AYNR PADH FEAR GQYV KFLA QTA
Gene ID:55256
Uniprot:Q9BV57
Cellular Location:Cell membrane, Cytoplasm, Cytoplasmic side, Nucleus, Peripheral membrane protein
Calculated MW:20kDa/21kDa
Observed MW:21kDa
UniProt Protein Function:ADI1: Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. Belongs to the acireductone dioxygenase (ARD) family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Amino Acid Metabolism - cysteine and methionine; EC 1.13.11.54; Oxidoreductase

Chromosomal Location of Human Ortholog: 2p25.3

Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function:acireductone dioxygenase [iron(II)-requiring] activity; protein binding; iron ion binding; oxidoreductase activity

Biological Process: methionine salvage; sulfur amino acid metabolic process; polyamine metabolic process

UniProt Code:Q9BV57
NCBI GenInfo Identifier:74733289
NCBI Gene ID:55256
NCBI Accession:Q9BV57.1
Molecular Weight:21kDa
NCBI Full Name:1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
UniProt Protein Name:1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
UniProt Synonym Protein Names:Acireductone dioxygenase (Fe(2+)-requiring); Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1
Protein Family:1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
UniProt Gene Name:ADI1  
UniProt Entry Name:MTND_HUMAN
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