Description
| Product Name: | ADI1 Rabbit pAb |
| Product Code: | CAB4820 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ADI1, APL1, ARD, Fe-ARD, HMFT1638, MTCBP1, Ni-ARD, SIPL, mtnD |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human ADI1 (NP_060739.2). |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, A-549, SGC-7901, HT-29, 293T, HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human ADI1 (NP_060739.2). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVQA WYMD DAPG DPRQ PHRP DPGR PVGL EQLR RLGV LYWK LDAD KYEN DPEL EKIR RERN YSWM DIIT ICKD KLPN YEEK IKMF YEEH LHLD DEIR YILD GSGY FDVR DKED QWIR IFME KGDM VTLP AGIY HRFT VDEK NYTK AMRL FVGE PVWT AYNR PADH FEAR GQYV KFLA QTA |
| Gene ID: | 55256 |
| Uniprot: | Q9BV57 |
| Cellular Location: | Cell membrane, Cytoplasm, Cytoplasmic side, Nucleus, Peripheral membrane protein |
| Calculated MW: | 20kDa/21kDa |
| Observed MW: | 21kDa |
| UniProt Protein Function: | ADI1: Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. Belongs to the acireductone dioxygenase (ARD) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - cysteine and methionine; EC 1.13.11.54; Oxidoreductase Chromosomal Location of Human Ortholog: 2p25.3 Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; plasma membrane; nucleus; cytosol Molecular Function:acireductone dioxygenase [iron(II)-requiring] activity; protein binding; iron ion binding; oxidoreductase activity Biological Process: methionine salvage; sulfur amino acid metabolic process; polyamine metabolic process |
| UniProt Code: | Q9BV57 |
| NCBI GenInfo Identifier: | 74733289 |
| NCBI Gene ID: | 55256 |
| NCBI Accession: | Q9BV57.1 |
| Molecular Weight: | 21kDa |
| NCBI Full Name: | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase |
| UniProt Protein Name: | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase |
| UniProt Synonym Protein Names: | Acireductone dioxygenase (Fe(2+)-requiring); Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1 |
| Protein Family: | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase |
| UniProt Gene Name: | ADI1Â Â |
| UniProt Entry Name: | MTND_HUMAN |
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