Signal Transduction Antibodies 1
Anti-ADAP2 Antibody (CAB13739)
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- SKU:
- CAB13739
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-ADAP2 Antibody |
| Antibody SKU: | CAB13739 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-381 of human ADAP2 (NP_060874.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-381 of human ADAP2 (NP_060874.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGDR ERNK KRLL ELLR APDT GNAH CADC GAAD PDWA SYKL GIFI CLNC CGVH RNFP DISR VKSV RLDF WDDS IVEF MIHN GNLR VKAK FEAR VPAF YYIP QAND CLVL KEQW IRAK YERR EFMA DGET ISLP GNRE GFLW KRGR DNSQ FLRR KFVL LARE GLLK YFTK EQGK SPKA VISI KDLN ATFQ TEKI GHPH GLQI TYRR DGHT RNLF VYHE SGKE IVDW FNAL RAAR LQYL KMAF PELP ESEL VPFL TRNY LKQG FMEK TGPK QKEP FKKR WFAL DCHE RRLL YYKN PLDA FEQG QVFL GNKE QGYE AYED LPKG IRGN RWKA GLTI VTPE RRFV LTCP SEKE QQEW LESL RGVL SSPL TPLN RLTA STES GRSS R |
| Gene ID: | 55803 |
| Uniprot: | Q9NPF8 |
| Cellular Location: | Cell membrane, Cytoplasm |
| Calculated MW: | 44kDa |
| Observed MW: | 44kDa |
| Synonyms: | ADAP2, CENTA2, HSA272195, cent-b |
| Background: | The protein encoded by this gene binds beta-tubulin and increases the stability of microtubules. The encoded protein can also translocate to the cell membrane and bind phosphatidylinositol 3, 4, 5-trisphosphate (PtdInsP3) and inositol 1, 3, 4, 5-tetrakisphosphate (InsP4). In addition, this protein is a GTPase-activating protein for ADP ribosylation factor 6 and may be able to block the entry of some RNA viruses. |
| UniProt Protein Function: | CENTA2: GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid-binding; Mitochondrial; GAPs; GAPs, ARF Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: mitochondrial envelope; cytoplasm; plasma membrane Molecular Function:protein binding, bridging; phosphatidylinositol-4,5-bisphosphate binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; inositol 1,3,4,5 tetrakisphosphate binding; zinc ion binding; phosphatidylinositol-3,4-bisphosphate binding Biological Process: heart development; positive regulation of GTPase activity |
| UniProt Code: | Q9NPF8 |
| NCBI GenInfo Identifier: | 27923749 |
| NCBI Gene ID: | 55803 |
| NCBI Accession: | Q9NPF8.1 |
| UniProt Secondary Accession: | Q9NPF8,Q8N4Q6, Q96SD5, |
| UniProt Related Accession: | Q9NPF8 |
| Molecular Weight: | 44,221 Da |
| NCBI Full Name: | Arf-GAP with dual PH domain-containing protein 2 |
| NCBI Synonym Full Names: | ArfGAP with dual PH domains 2 |
| NCBI Official Symbol: | ADAP2 |
| NCBI Official Synonym Symbols: | CENTA2; cent-b; HSA272195 |
| NCBI Protein Information: | arf-GAP with dual PH domain-containing protein 2; centaurin beta; centaurin, alpha 2; centaurin-alpha 2 protein; centaurin-alpha-2; cnt-a2 |
| UniProt Protein Name: | Arf-GAP with dual PH domain-containing protein 2 |
| UniProt Synonym Protein Names: | Centaurin-alpha-2; Cnt-a2 |
| Protein Family: | Arf-GAP with dual PH domain-containing protein |
| UniProt Gene Name: | ADAP2 |
| UniProt Entry Name: | ADAP2_HUMAN |
 | Western blot analysis of extracts of 293T cells, using ADAP2 antibody (CAB13739) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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