Signal Transduction Antibodies 1

Anti-ACTL7B Antibody (CAB13149)

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SKU:
CAB13149
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-ACTL7B Antibody
Antibody SKU:CAB13149
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-380 of human ACTL7B (NP_006677.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, LO2, Mouse brain, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-380 of human ACTL7B (NP_006677.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GHGV SHVV PISE GDVL PGLT SRAD YAGG DLTN YLMQ LLNE AGHA FTDD HLHI IEHI KKKC CYAA FLPE EELG LVPE ELRV DYEL PDGK LITI GQER FRCS EMLF QPSL AGST QPGL PELT AACL GRCQ DTGF KEEM AANV LLCG GCTM LDGF PERF QREL SLLC PGDS PAVA AAPE RKTS V
Gene ID:10880
Uniprot:Q9Y614
Cellular Location:Cytoplasm, cytoskeleton
Calculated MW:45kDa
Observed MW:45kDa
Synonyms:ACTL7B, Tact1
Background:The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known.
UniProt Protein Function:ACTL7B: is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q31

Cellular Component: actin cytoskeleton

Molecular Function:structural constituent of cytoskeleton

NCBI Summary:The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y614
NCBI GenInfo Identifier:27923724
NCBI Gene ID:10880
NCBI Accession:Q9Y614.1
UniProt Secondary Accession:Q9Y614,Q5JSV1, B2R9Q2,
UniProt Related Accession:Q9Y614
Molecular Weight:45,234 Da
NCBI Full Name:Actin-like protein 7B
NCBI Synonym Full Names:actin like 7B
NCBI Official Symbol:ACTL7B  
NCBI Official Synonym Symbols:Tact1  
NCBI Protein Information:actin-like protein 7B
UniProt Protein Name:Actin-like protein 7B
UniProt Synonym Protein Names:Actin-like-7-beta
Protein Family:Actin-like protein
UniProt Gene Name:ACTL7B  
UniProt Entry Name:ACL7B_HUMAN
Anti-ACTL7B Antibody (CAB13149)Western blot analysis of extracts of various cell lines, using ACTL7B antibody (CAB13149) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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