Metabolism Antibodies 3
Anti-Aconitase 2 Antibody (CAB4524)
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- SKU:
- CAB4524
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-Aconitase 2 Antibody |
| Antibody SKU: | CAB4524 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Aconitase 2 |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Jurkat, SH-SY5Y, Mouse brain, Mouse kidney, Mouse heart, Rat brain, Rat heart |
| Immunogen: | A synthesized peptide derived from human Aconitase 2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 50 |
| Uniprot: | Q99798 |
| Cellular Location: | |
| Calculated MW: | 85kDa |
| Observed MW: | 85KDa |
| Synonyms: | ACONM, HEL-S-284, ICRD, OCA8, OPA9 |
| Background: | The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | ACO2: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. Monomer. Belongs to the aconitase/IPM isomerase family. |
| UniProt Protein Details: | Protein type:Lyase; EC 4.2.1.3; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - citrate (TCA) cycle; Mitochondrial Chromosomal Location of Human Ortholog: 22q13.2 Cellular Component: mitochondrion; mitochondrial matrix; nucleus Molecular Function:iron ion binding; 4 iron, 4 sulfur cluster binding; aconitate hydratase activity; 3 iron, 4 sulfur cluster binding Biological Process: isocitrate metabolic process; cellular metabolic process; generation of precursor metabolites and energy; tricarboxylic acid cycle; citrate metabolic process Disease: Infantile Cerebellar-retinal Degeneration; Optic Atrophy 8 |
| NCBI Summary: | The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99798 |
| NCBI GenInfo Identifier: | 6686275 |
| NCBI Gene ID: | 50 |
| NCBI Accession: | Q99798.2 |
| UniProt Related Accession: | Q99798 |
| Molecular Weight: | |
| NCBI Full Name: | Aconitate hydratase, mitochondrial |
| NCBI Synonym Full Names: | aconitase 2 |
| NCBI Official Symbol: | ACO2 |
| NCBI Official Synonym Symbols: | ICRD; OCA8; OPA9; ACONM; HEL-S-284 |
| NCBI Protein Information: | aconitate hydratase, mitochondrial |
| UniProt Protein Name: | Aconitate hydratase, mitochondrial |
| UniProt Synonym Protein Names: | Citrate hydro-lyase |
| Protein Family: | Aconitate hydratase |
| UniProt Gene Name: | ACO2 |
| UniProt Entry Name: | ACON_HUMAN |
 | Western blot - Aconitase 2 Rabbit mAb (CAB4524) |
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