Metabolism Antibodies 3
Anti-ACLY Antibody (CAB3719)
- SKU:
- CAB3719
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
Antibody Name: | Anti-ACLY Antibody |
Antibody SKU: | CAB3719 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IF |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A synthesized peptide derived from human ACLY |
Application: | WB IF |
Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | HeLa, HepG2, Jurkat, Mouse lung, Mouse liver, Mouse brain, Rat lung, Rat liver |
Immunogen: | A synthesized peptide derived from human ACLY |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 47 |
Uniprot: | P53396 |
Cellular Location: | Cytoplasm |
Calculated MW: | 122kDa |
Observed MW: | 125KDa |
Synonyms: | ACL, ATPCL, CLATP |
Background: | ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440, 000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014] |
UniProt Protein Function: | ACLY: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. Homotetramer. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 2.3.3.8; Transferase; Lyase; Carbohydrate Metabolism - citrate (TCA) cycle Chromosomal Location of Human Ortholog: 17q21.2 Cellular Component: cytoplasm; cytosol; membrane; mitochondrion; nucleoplasm; plasma membrane Molecular Function:ATP binding; ATP citrate synthase activity; cofactor binding; metal ion binding; protein binding Biological Process: acetyl-CoA biosynthetic process; cellular lipid metabolic process; cholesterol biosynthetic process; citrate metabolic process; energy reserve metabolic process; fatty acid biosynthetic process; lipid biosynthetic process; oxaloacetate metabolic process; positive regulation of cellular metabolic process; triacylglycerol biosynthetic process |
NCBI Summary: | ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014] |
UniProt Code: | P53396 |
NCBI GenInfo Identifier: | 116241237 |
NCBI Gene ID: | 47 |
NCBI Accession: | P53396.3 |
UniProt Secondary Accession: | P53396,Q13037, Q9BRL0, B4DIM0, B4E3P0, |
UniProt Related Accession: | P53396 |
Molecular Weight: | 91,099 Da |
NCBI Full Name: | ATP-citrate synthase |
NCBI Synonym Full Names: | ATP citrate lyase |
NCBI Official Symbol: | ACLY |
NCBI Official Synonym Symbols: | ACL; ATPCL; CLATP |
NCBI Protein Information: | ATP-citrate synthase |
UniProt Protein Name: | ATP-citrate synthase |
UniProt Synonym Protein Names: | ATP-citrate (pro-S-)-lyase; ACL; Citrate cleavage enzyme |
Protein Family: | ATP-citrate synthase |
UniProt Gene Name: | ACLY |
UniProt Entry Name: | ACLY_HUMAN |
View AllClose